Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors
Abstract The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut microbiota may be altered during various pathological conditions and produce a number of toxic compounds an...
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doaj-ef02f634a43c487992f2f396c661b4e22021-02-22T07:32:52ZengWileyCancer Medicine2045-76342021-02-011031141115410.1002/cam4.3694Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitorsSama Rezasoltani0Abbas Yadegar1Hamid Asadzadeh Aghdaei2Mohammad Reza Zali3Foodborne and Waterborne Diseases Research Center Research Institute for Gastroenterology and Liver DiseasesShahid Beheshti University of Medical Sciences Tehran IranFoodborne and Waterborne Diseases Research Center Research Institute for Gastroenterology and Liver DiseasesShahid Beheshti University of Medical Sciences Tehran IranBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center Research Institute for Gastroenterology and Liver DiseasesShahid Beheshti University of Medical Sciences Tehran IranGastroenterology and Liver Diseases Research Center Research Institute for Gastroenterology and Liver DiseasesShahid Beheshti University of Medical Sciences Tehran IranAbstract The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut microbiota may be altered during various pathological conditions and produce a number of toxic compounds and oncoproteins, in turn, to induce both inflammatory response and carcinogenesis. Recently, promising findings have been documented toward the implementation of certain intestinal microbiome in the next era of cancer biology and cancer immunotherapy. Notably, intestinal microbiota can cooperate with immune checkpoint inhibitors (ICIs) of its host, especially in enhancing the efficacy of programmed death 1 (PD‐1) protein and its ligand programmed death ligand 1 (PD‐L1) blockade therapy for cancer. Herein, we review the dual function of gut microbiota in triggering GI cancers, its association with host immunity and its beneficial functions in modulation of cancer immunotherapy responses. Furthermore, we consider the significance of gut microbiota as a potential biomarker for predicting the efficacy of cancer immunotherapy. Finally, we summarize the relevant limitations that affect the effectiveness and clinical applications of gut microbiome in response to immunotherapy.https://doi.org/10.1002/cam4.3694cancer immunotherapygut microbiomarkersgut microbiotaimmune checkpoint inhibitorsoncomicrobesPD‐1/PD‐L1 inhibitors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sama Rezasoltani Abbas Yadegar Hamid Asadzadeh Aghdaei Mohammad Reza Zali |
spellingShingle |
Sama Rezasoltani Abbas Yadegar Hamid Asadzadeh Aghdaei Mohammad Reza Zali Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors Cancer Medicine cancer immunotherapy gut microbiomarkers gut microbiota immune checkpoint inhibitors oncomicrobes PD‐1/PD‐L1 inhibitors |
author_facet |
Sama Rezasoltani Abbas Yadegar Hamid Asadzadeh Aghdaei Mohammad Reza Zali |
author_sort |
Sama Rezasoltani |
title |
Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors |
title_short |
Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors |
title_full |
Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors |
title_fullStr |
Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors |
title_full_unstemmed |
Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors |
title_sort |
modulatory effects of gut microbiome in cancer immunotherapy: a novel paradigm for blockade of immune checkpoint inhibitors |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-02-01 |
description |
Abstract The human gastrointestinal (GI) tract harbors gut microbiome, which plays a crucial role in preserving homeostasis at the intestinal host‐microbial interface. Conversely, specific gut microbiota may be altered during various pathological conditions and produce a number of toxic compounds and oncoproteins, in turn, to induce both inflammatory response and carcinogenesis. Recently, promising findings have been documented toward the implementation of certain intestinal microbiome in the next era of cancer biology and cancer immunotherapy. Notably, intestinal microbiota can cooperate with immune checkpoint inhibitors (ICIs) of its host, especially in enhancing the efficacy of programmed death 1 (PD‐1) protein and its ligand programmed death ligand 1 (PD‐L1) blockade therapy for cancer. Herein, we review the dual function of gut microbiota in triggering GI cancers, its association with host immunity and its beneficial functions in modulation of cancer immunotherapy responses. Furthermore, we consider the significance of gut microbiota as a potential biomarker for predicting the efficacy of cancer immunotherapy. Finally, we summarize the relevant limitations that affect the effectiveness and clinical applications of gut microbiome in response to immunotherapy. |
topic |
cancer immunotherapy gut microbiomarkers gut microbiota immune checkpoint inhibitors oncomicrobes PD‐1/PD‐L1 inhibitors |
url |
https://doi.org/10.1002/cam4.3694 |
work_keys_str_mv |
AT samarezasoltani modulatoryeffectsofgutmicrobiomeincancerimmunotherapyanovelparadigmforblockadeofimmunecheckpointinhibitors AT abbasyadegar modulatoryeffectsofgutmicrobiomeincancerimmunotherapyanovelparadigmforblockadeofimmunecheckpointinhibitors AT hamidasadzadehaghdaei modulatoryeffectsofgutmicrobiomeincancerimmunotherapyanovelparadigmforblockadeofimmunecheckpointinhibitors AT mohammadrezazali modulatoryeffectsofgutmicrobiomeincancerimmunotherapyanovelparadigmforblockadeofimmunecheckpointinhibitors |
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