Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study

• Main Authors: Adilha Misson Rua Micheletti, Ana Cristina Araújo Lemos da Silva, Antonio Geraldo Nascimento, Cléber Sérgio da Silva, Eddie Fernando Candido Murta, Sheila Jorge Adad
• Format: Article
• Language: English
• Published: Associação Paulista de Medicina
• Series: São Paulo Medical Journal
• Subjects: Angiofibroma; Connective tissue; Mesoderm; Neoplasm; Vulva
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000500010&lng=en&tlng=en

CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins. CASE REPORT: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.