Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative
Subchondral bone marrow lesions (BMLs) are related to structural and symptomatic osteoarthritis progression. However, it is unclear how sequence selection influences a quantitative BML measurement and its construct validity. We compared quantitative assessment of BMLs on intermediate-weighted fat su...
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Online Access: | http://dx.doi.org/10.1155/2015/731903 |
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doaj-ef0d6cf7e8234da48ba71333883b93c32020-11-24T20:54:57ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/731903731903Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis InitiativeMing Zhang0Jeffrey B. Driban1Lori Lyn Price2Grace H. Lo3Timothy E. McAlindon4Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USADivision of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USAThe Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts Clinical and Translational Science Institute, Tufts University, 800 Washington Street, Box No. 63, Boston, MA 02111, USAMedical Care Line and Research Care Line, Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VAMC, Houston, TX 77030, USADivision of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USASubchondral bone marrow lesions (BMLs) are related to structural and symptomatic osteoarthritis progression. However, it is unclear how sequence selection influences a quantitative BML measurement and its construct validity. We compared quantitative assessment of BMLs on intermediate-weighted fat suppressed (IW FS) turbo spin echo and 3-dimensional dual echo steady state (3D DESS) sequences. We used a customized software to measure 30 knees’ (24- and 48-month MR images) BMLs on both sequences. The results showed that the IW FS sequences have much larger BML volumes (median: IW FS = 1840 mm3; DESS = 191 mm3) and BML volume change (between 24 and 48 months) than DESS sequence and demonstrate more BML volume change. The 24-month BML volume on IW FS is correlated with BML volume on DESS (rs = 0.83). BML volume change on IW FS is not significantly correlated with change on DESS. The 24-month WOMAC pain is correlated with the 24-month BMLs on IW FS (rs = 0.39) but not DESS. The change in WOMAC pain is correlated with BML volume change on IW FS (rs = 0.37) but not DESS. Overall, BML quantification on IW FS offers better validity and statistical power than BML quantification on a 3D DESS sequence.http://dx.doi.org/10.1155/2015/731903 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming Zhang Jeffrey B. Driban Lori Lyn Price Grace H. Lo Timothy E. McAlindon |
spellingShingle |
Ming Zhang Jeffrey B. Driban Lori Lyn Price Grace H. Lo Timothy E. McAlindon Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative BioMed Research International |
author_facet |
Ming Zhang Jeffrey B. Driban Lori Lyn Price Grace H. Lo Timothy E. McAlindon |
author_sort |
Ming Zhang |
title |
Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative |
title_short |
Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative |
title_full |
Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative |
title_fullStr |
Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative |
title_full_unstemmed |
Magnetic Resonance Image Sequence Influences the Relationship between Bone Marrow Lesions Volume and Pain: Data from the Osteoarthritis Initiative |
title_sort |
magnetic resonance image sequence influences the relationship between bone marrow lesions volume and pain: data from the osteoarthritis initiative |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Subchondral bone marrow lesions (BMLs) are related to structural and symptomatic osteoarthritis progression. However, it is unclear how sequence selection influences a quantitative BML measurement and its construct validity. We compared quantitative assessment of BMLs on intermediate-weighted fat suppressed (IW FS) turbo spin echo and 3-dimensional dual echo steady state (3D DESS) sequences. We used a customized software to measure 30 knees’ (24- and 48-month MR images) BMLs on both sequences. The results showed that the IW FS sequences have much larger BML volumes (median: IW FS = 1840 mm3; DESS = 191 mm3) and BML volume change (between 24 and 48 months) than DESS sequence and demonstrate more BML volume change. The 24-month BML volume on IW FS is correlated with BML volume on DESS (rs = 0.83). BML volume change on IW FS is not significantly correlated with change on DESS. The 24-month WOMAC pain is correlated with the 24-month BMLs on IW FS (rs = 0.39) but not DESS. The change in WOMAC pain is correlated with BML volume change on IW FS (rs = 0.37) but not DESS. Overall, BML quantification on IW FS offers better validity and statistical power than BML quantification on a 3D DESS sequence. |
url |
http://dx.doi.org/10.1155/2015/731903 |
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