Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

Bacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and present a general approach that can predict bacteri...

Full description

Bibliographic Details
Main Authors: Zeyu Zhu, Defne Surujon, Juan C. Ortiz-Marquez, Wenwen Huo, Ralph R. Isberg, José Bento, Tim van Opijnen
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18134-z
id doaj-ef0fe239e15245d990fc0ccfb009ce26
record_format Article
spelling doaj-ef0fe239e15245d990fc0ccfb009ce262021-09-05T11:45:14ZengNature Publishing GroupNature Communications2041-17232020-08-0111111510.1038/s41467-020-18134-zEntropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivityZeyu Zhu0Defne Surujon1Juan C. Ortiz-Marquez2Wenwen Huo3Ralph R. Isberg4José Bento5Tim van Opijnen6Biology Department, Boston CollegeBiology Department, Boston CollegeBiology Department, Boston CollegeDepartment of Molecular Biology and Microbiology, Tufts University School of MedicineDepartment of Molecular Biology and Microbiology, Tufts University School of MedicineComputer Science Department, Boston CollegeBiology Department, Boston CollegeBacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and present a general approach that can predict bacterial fitness independently of species or type of stress.https://doi.org/10.1038/s41467-020-18134-z
collection DOAJ
language English
format Article
sources DOAJ
author Zeyu Zhu
Defne Surujon
Juan C. Ortiz-Marquez
Wenwen Huo
Ralph R. Isberg
José Bento
Tim van Opijnen
spellingShingle Zeyu Zhu
Defne Surujon
Juan C. Ortiz-Marquez
Wenwen Huo
Ralph R. Isberg
José Bento
Tim van Opijnen
Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
Nature Communications
author_facet Zeyu Zhu
Defne Surujon
Juan C. Ortiz-Marquez
Wenwen Huo
Ralph R. Isberg
José Bento
Tim van Opijnen
author_sort Zeyu Zhu
title Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_short Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_full Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_fullStr Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_full_unstemmed Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
title_sort entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description Bacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and present a general approach that can predict bacterial fitness independently of species or type of stress.
url https://doi.org/10.1038/s41467-020-18134-z
work_keys_str_mv AT zeyuzhu entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
AT defnesurujon entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
AT juancortizmarquez entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
AT wenwenhuo entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
AT ralphrisberg entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
AT josebento entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
AT timvanopijnen entropyofabacterialstressresponseisageneralizablepredictorforfitnessandantibioticsensitivity
_version_ 1717814015249350656

Similar Items