Unfolded protein response in myelin disorders
Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studi...
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Wolters Kluwer Medknow Publications
2020-01-01
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doaj-ef1154b383a5460b8d81ec070bc54f502020-11-25T03:06:36ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742020-01-0115463664510.4103/1673-5374.266903Unfolded protein response in myelin disordersWensheng LinSarrabeth StoneActivation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin, including multiples sclerosis, Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, vanishing white matter disease, spinal cord injury, tuberous sclerosis complex, and hypoxia-induced perinatal white matter injury. In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=4;spage=636;epage=645;aulast=Linaxon; er; multiples sclerosis; myelin; oligodendrocyte; schwann cell; spinal cord injury; upr |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wensheng Lin Sarrabeth Stone |
spellingShingle |
Wensheng Lin Sarrabeth Stone Unfolded protein response in myelin disorders Neural Regeneration Research axon; er; multiples sclerosis; myelin; oligodendrocyte; schwann cell; spinal cord injury; upr |
author_facet |
Wensheng Lin Sarrabeth Stone |
author_sort |
Wensheng Lin |
title |
Unfolded protein response in myelin disorders |
title_short |
Unfolded protein response in myelin disorders |
title_full |
Unfolded protein response in myelin disorders |
title_fullStr |
Unfolded protein response in myelin disorders |
title_full_unstemmed |
Unfolded protein response in myelin disorders |
title_sort |
unfolded protein response in myelin disorders |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2020-01-01 |
description |
Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin, including multiples sclerosis, Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, vanishing white matter disease, spinal cord injury, tuberous sclerosis complex, and hypoxia-induced perinatal white matter injury. In this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders. |
topic |
axon; er; multiples sclerosis; myelin; oligodendrocyte; schwann cell; spinal cord injury; upr |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=4;spage=636;epage=645;aulast=Lin |
work_keys_str_mv |
AT wenshenglin unfoldedproteinresponseinmyelindisorders AT sarrabethstone unfoldedproteinresponseinmyelindisorders |
_version_ |
1724673489649008640 |