Lysosomal Calcium Channels in Autophagy and Cancer
Ca<sup>2+</sup> is pivotal intracellular messenger that coordinates multiple cell functions such as fertilization, growth, differentiation, and viability. Intracellular Ca<sup>2+</sup> signaling is regulated by both extracellular Ca<sup>2+</sup> entry and Ca<su...
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Online Access: | https://www.mdpi.com/2072-6694/13/6/1299 |
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doaj-ef1163d821604fc4af392edb57e804472021-03-16T00:00:45ZengMDPI AGCancers2072-66942021-03-01131299129910.3390/cancers13061299Lysosomal Calcium Channels in Autophagy and CancerYi Wu0Peng Huang1Xian-Ping Dong2Collaborative Innovation Center for Biomedicine, School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaCollaborative Innovation Center for Biomedicine, School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, ChinaDepartments of Physiology and Biophysics, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, CanadaCa<sup>2+</sup> is pivotal intracellular messenger that coordinates multiple cell functions such as fertilization, growth, differentiation, and viability. Intracellular Ca<sup>2+</sup> signaling is regulated by both extracellular Ca<sup>2+</sup> entry and Ca<sup>2+</sup> release from intracellular stores. Apart from working as the cellular recycling center, the lysosome has been increasingly recognized as a significant intracellular Ca<sup>2+</sup> store that provides Ca<sup>2+</sup> to regulate many cellular processes. The lysosome also talks to other organelles by releasing and taking up Ca<sup>2+</sup>. In lysosomal Ca<sup>2+</sup>-dependent processes, autophagy is particularly important, because it has been implicated in many human diseases including cancer. This review will discuss the major components of lysosomal Ca<sup>2+</sup> stores and their roles in autophagy and human cancer progression.https://www.mdpi.com/2072-6694/13/6/1299lysosomeion channelcalciumautophagycancer |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi Wu Peng Huang Xian-Ping Dong |
spellingShingle |
Yi Wu Peng Huang Xian-Ping Dong Lysosomal Calcium Channels in Autophagy and Cancer Cancers lysosome ion channel calcium autophagy cancer |
author_facet |
Yi Wu Peng Huang Xian-Ping Dong |
author_sort |
Yi Wu |
title |
Lysosomal Calcium Channels in Autophagy and Cancer |
title_short |
Lysosomal Calcium Channels in Autophagy and Cancer |
title_full |
Lysosomal Calcium Channels in Autophagy and Cancer |
title_fullStr |
Lysosomal Calcium Channels in Autophagy and Cancer |
title_full_unstemmed |
Lysosomal Calcium Channels in Autophagy and Cancer |
title_sort |
lysosomal calcium channels in autophagy and cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-03-01 |
description |
Ca<sup>2+</sup> is pivotal intracellular messenger that coordinates multiple cell functions such as fertilization, growth, differentiation, and viability. Intracellular Ca<sup>2+</sup> signaling is regulated by both extracellular Ca<sup>2+</sup> entry and Ca<sup>2+</sup> release from intracellular stores. Apart from working as the cellular recycling center, the lysosome has been increasingly recognized as a significant intracellular Ca<sup>2+</sup> store that provides Ca<sup>2+</sup> to regulate many cellular processes. The lysosome also talks to other organelles by releasing and taking up Ca<sup>2+</sup>. In lysosomal Ca<sup>2+</sup>-dependent processes, autophagy is particularly important, because it has been implicated in many human diseases including cancer. This review will discuss the major components of lysosomal Ca<sup>2+</sup> stores and their roles in autophagy and human cancer progression. |
topic |
lysosome ion channel calcium autophagy cancer |
url |
https://www.mdpi.com/2072-6694/13/6/1299 |
work_keys_str_mv |
AT yiwu lysosomalcalciumchannelsinautophagyandcancer AT penghuang lysosomalcalciumchannelsinautophagyandcancer AT xianpingdong lysosomalcalciumchannelsinautophagyandcancer |
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