An immunohistochemical analysis of tissue thrombin expression in the human atria.

OBJECTIVE: Thrombin, the final coagulation product of the coagulation cascade, has been demonstrated to have many physiological effects, including pro-fibrotic actions via protease-activated receptor (PAR)-1. Recent investigations have demonstrated that activation of the cardiac local coagulation sy...

Full description

Bibliographic Details
Main Authors: Keiichi Ito, Taro Date, Masahiro Ikegami, Kenichi Hongo, Masami Fujisaki, Daisuke Katoh, Takuya Yoshino, Ryuko Anzawa, Tomohisa Nagoshi, Seigo Yamashita, Keiichi Inada, Seiichiro Matsuo, Teiichi Yamane, Michihiro Yoshimura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3681873?pdf=render