CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism

CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism

Cholangiocarcinoma is a disease with a poor prognosis and increasing incidence and hence there is a pressing unmet clinical need for new adjuvant treatments. Protein kinase CK2 (previously casein kinase II) is a ubiquitously expressed protein kinase that is up-regulated in multiple cancer cell types...

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Bibliographic Details
Main Authors: Jomnarong Lertsuwan, Kornkamon Lertsuwan, Anyaporn Sawasdichai, Nathapol Tasnawijitwong, Ka Ying Lee, Philip Kitchen, Simon Afford, Kevin Gaston, Padma-Sheela Jayaraman, Jutamaad Satayavivad
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Cancers
Subjects:
protein kinase CK2
CX-4945
cholangiocarcinoma
non-canonical cell death
methuosis
Online Access:http://www.mdpi.com/2072-6694/10/9/283

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