Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate agin...

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Main Authors: Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Guang-Hui Liu
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10831-8
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spelling doaj-ef27753ea31d478c8881938090f2b42a2021-05-11T12:19:05ZengNature Publishing GroupNature Communications2041-17232019-07-0110111610.1038/s41467-019-10831-8Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritisLiping Deng0Ruotong Ren1Zunpeng Liu2Moshi Song3Jingyi Li4Zeming Wu5Xiaoqing Ren6Lina Fu7Wei Li8Weiqi Zhang9Pedro Guillen10Juan Carlos Izpisua Belmonte11Piu Chan12Jing Qu13Guang-Hui Liu14National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical UniversityNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesClinica Cemtro. Av. del Ventisquero de la Condesa, 42Gene Expression Laboratory, Salk Institute for Biological StudiesAdvanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical UniversityState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesDGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescencehttps://doi.org/10.1038/s41467-019-10831-8
collection DOAJ
language English
format Article
sources DOAJ
author Liping Deng
Ruotong Ren
Zunpeng Liu
Moshi Song
Jingyi Li
Zeming Wu
Xiaoqing Ren
Lina Fu
Wei Li
Weiqi Zhang
Pedro Guillen
Juan Carlos Izpisua Belmonte
Piu Chan
Jing Qu
Guang-Hui Liu
spellingShingle Liping Deng
Ruotong Ren
Zunpeng Liu
Moshi Song
Jingyi Li
Zeming Wu
Xiaoqing Ren
Lina Fu
Wei Li
Weiqi Zhang
Pedro Guillen
Juan Carlos Izpisua Belmonte
Piu Chan
Jing Qu
Guang-Hui Liu
Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
Nature Communications
author_facet Liping Deng
Ruotong Ren
Zunpeng Liu
Moshi Song
Jingyi Li
Zeming Wu
Xiaoqing Ren
Lina Fu
Wei Li
Weiqi Zhang
Pedro Guillen
Juan Carlos Izpisua Belmonte
Piu Chan
Jing Qu
Guang-Hui Liu
author_sort Liping Deng
title Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_short Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_full Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_fullStr Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_full_unstemmed Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
title_sort stabilizing heterochromatin by dgcr8 alleviates senescence and osteoarthritis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-07-01
description DGCR8 is a component of the canonical microprocessor complex for microRNA biogenesis. Here the authors implicate DGCR8 in heterochromatin maintenance and aging attenuation independent of its miRNA-processing activity through Lamin B1, KAP1 and HP1 interaction. DGCR8 overexpression can alleviate aging and senescence
url https://doi.org/10.1038/s41467-019-10831-8
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