Tumor Necrosis Factor-Alpha and Age-Related Pathologies
Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory dise...
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SINAPS LLC
2020-12-01
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Online Access: | https://www.medarhive.ru/jour/article/view/1104 |
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doaj-ef289e79b5324b33a9c50f5b56a3e1952021-07-29T08:11:37ZrusSINAPS LLCArhivʺ Vnutrennej Mediciny2226-67042411-65642020-12-0110641442110.20514/2226-6704-2020-10-6-414-421815Tumor Necrosis Factor-Alpha and Age-Related PathologiesS. V. Topolyanskaya0I.M. Sechenov First Moscow State Medical University (Sechenov University), RF Health MinistryModern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory diseases as well as in aging. The increased levels of tumor necrosis factor-α leads to the onset and progression of various diseases, to severity of frailty, to disability and mortality of elderly persons. Tumor necrosis factor-α affects different risk factors for cardiovascular diseases, contributes to the onset and progression of atherosclerosis and related pathology. This cytokine can also aggravate various metabolic disorders, mainly — insulin resistance and diabetes mellitus. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (up to osteoporosis) and sarcopenia (up to cachexia). Currently available data confirm the important role of tumor necrosis factor-α in various age-associated disorders.https://www.medarhive.ru/jour/article/view/1104inflammationcytokinestumor necrosis factor-α (tnf-α)atherosclerosisagingold agelong-livers |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
S. V. Topolyanskaya |
spellingShingle |
S. V. Topolyanskaya Tumor Necrosis Factor-Alpha and Age-Related Pathologies Arhivʺ Vnutrennej Mediciny inflammation cytokines tumor necrosis factor-α (tnf-α) atherosclerosis aging old age long-livers |
author_facet |
S. V. Topolyanskaya |
author_sort |
S. V. Topolyanskaya |
title |
Tumor Necrosis Factor-Alpha and Age-Related Pathologies |
title_short |
Tumor Necrosis Factor-Alpha and Age-Related Pathologies |
title_full |
Tumor Necrosis Factor-Alpha and Age-Related Pathologies |
title_fullStr |
Tumor Necrosis Factor-Alpha and Age-Related Pathologies |
title_full_unstemmed |
Tumor Necrosis Factor-Alpha and Age-Related Pathologies |
title_sort |
tumor necrosis factor-alpha and age-related pathologies |
publisher |
SINAPS LLC |
series |
Arhivʺ Vnutrennej Mediciny |
issn |
2226-6704 2411-6564 |
publishDate |
2020-12-01 |
description |
Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in the pathogenesis of chronic inflammatory diseases as well as in aging. The increased levels of tumor necrosis factor-α leads to the onset and progression of various diseases, to severity of frailty, to disability and mortality of elderly persons. Tumor necrosis factor-α affects different risk factors for cardiovascular diseases, contributes to the onset and progression of atherosclerosis and related pathology. This cytokine can also aggravate various metabolic disorders, mainly — insulin resistance and diabetes mellitus. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (up to osteoporosis) and sarcopenia (up to cachexia). Currently available data confirm the important role of tumor necrosis factor-α in various age-associated disorders. |
topic |
inflammation cytokines tumor necrosis factor-α (tnf-α) atherosclerosis aging old age long-livers |
url |
https://www.medarhive.ru/jour/article/view/1104 |
work_keys_str_mv |
AT svtopolyanskaya tumornecrosisfactoralphaandagerelatedpathologies |
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1721257187686219776 |