Seronegative neurobrucellosis—do we need new neurobrucellosis criteria?
Neurobrucellosis presents in various clinical forms and should always be considered in neurological patients in highly endemic areas such as the Mediterranean basin. Establishing a diagnosis can be challenging since serological testing can sometimes yield negative results. We present a rare case of...
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2021-10-01
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doaj-ef318a19c3e94e4a9940d4277a0745692021-10-03T04:38:43ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-01111124126Seronegative neurobrucellosis—do we need new neurobrucellosis criteria?Vassilis E. Papadopoulos0Kostas Patas1Argyro Tountopoulou2Georgios Velonakis3Fotini Boufidou4Stylianos Chatzipanagiotou5Sofia Vassilopoulou6First Department of Neurology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, Greece; Corresponding author: Vassilis E. Papadopoulos, First Department of Neurology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, Greece. Tel: +30 6973038628. Fax: +30 2107216474Department of Medical Biopathology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, GreeceFirst Department of Neurology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, GreeceResearch Unit of Radiology, Second Department of Radiology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, GreeceDepartment of Medical Biopathology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, GreeceDepartment of Medical Biopathology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, GreeceFirst Department of Neurology, National and Kapodistrian University of Athens, Eginition Hospital, Vas. Sofias 72, 11528, Athens, GreeceNeurobrucellosis presents in various clinical forms and should always be considered in neurological patients in highly endemic areas such as the Mediterranean basin. Establishing a diagnosis can be challenging since serological testing can sometimes yield negative results. We present a rare case of a seronegative relapse of neurobrucellosis in a patient who had been successfully treated for systemic brucellosis. Oligoclonal bands, an agglutination test, and 16S rRNA sequencing of cerebrospinal fluid proved essential in unmasking a confined central nervous system relapse. This case reinforces the need for establishing diagnostic criteria for neurobrucellosis, which could potentially include oligoclonal bands and an agglutination test on the cerebrospinal fluid.http://www.sciencedirect.com/science/article/pii/S1201971221006718BrucellosisAgglutination testsOligoclonal bandsRNA, ribosomal, 16S |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vassilis E. Papadopoulos Kostas Patas Argyro Tountopoulou Georgios Velonakis Fotini Boufidou Stylianos Chatzipanagiotou Sofia Vassilopoulou |
spellingShingle |
Vassilis E. Papadopoulos Kostas Patas Argyro Tountopoulou Georgios Velonakis Fotini Boufidou Stylianos Chatzipanagiotou Sofia Vassilopoulou Seronegative neurobrucellosis—do we need new neurobrucellosis criteria? International Journal of Infectious Diseases Brucellosis Agglutination tests Oligoclonal bands RNA, ribosomal, 16S |
author_facet |
Vassilis E. Papadopoulos Kostas Patas Argyro Tountopoulou Georgios Velonakis Fotini Boufidou Stylianos Chatzipanagiotou Sofia Vassilopoulou |
author_sort |
Vassilis E. Papadopoulos |
title |
Seronegative neurobrucellosis—do we need new neurobrucellosis criteria? |
title_short |
Seronegative neurobrucellosis—do we need new neurobrucellosis criteria? |
title_full |
Seronegative neurobrucellosis—do we need new neurobrucellosis criteria? |
title_fullStr |
Seronegative neurobrucellosis—do we need new neurobrucellosis criteria? |
title_full_unstemmed |
Seronegative neurobrucellosis—do we need new neurobrucellosis criteria? |
title_sort |
seronegative neurobrucellosis—do we need new neurobrucellosis criteria? |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-10-01 |
description |
Neurobrucellosis presents in various clinical forms and should always be considered in neurological patients in highly endemic areas such as the Mediterranean basin. Establishing a diagnosis can be challenging since serological testing can sometimes yield negative results. We present a rare case of a seronegative relapse of neurobrucellosis in a patient who had been successfully treated for systemic brucellosis. Oligoclonal bands, an agglutination test, and 16S rRNA sequencing of cerebrospinal fluid proved essential in unmasking a confined central nervous system relapse. This case reinforces the need for establishing diagnostic criteria for neurobrucellosis, which could potentially include oligoclonal bands and an agglutination test on the cerebrospinal fluid. |
topic |
Brucellosis Agglutination tests Oligoclonal bands RNA, ribosomal, 16S |
url |
http://www.sciencedirect.com/science/article/pii/S1201971221006718 |
work_keys_str_mv |
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