Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2...

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Bibliographic Details
Main Authors: Claudia R. L. Cardoso, Gil F. Salles
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
arterial stiffness
type 2 diabetes
carotid-femoral pulse wave velocity
microvascular and macrovascular complications
Online Access:http://www.mdpi.com/1422-0067/17/12/2044
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spelling doaj-ef3242f843e640809c7358d1dcb139772020-11-24T22:06:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-12-011712204410.3390/ijms17122044ijms17122044Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 DiabetesClaudia R. L. Cardoso0Gil F. Salles1Department of Internal Medicine, School of Medicine and University Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Rodolpho Rocco 255, Cidade Universitária, Rio de Janeiro-RJ 21941-901, BrazilDepartment of Internal Medicine, School of Medicine and University Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Rodolpho Rocco 255, Cidade Universitária, Rio de Janeiro-RJ 21941-901, BrazilIncreased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.http://www.mdpi.com/1422-0067/17/12/2044arterial stiffnesstype 2 diabetescarotid-femoral pulse wave velocitymicrovascular and macrovascular complications
collection DOAJ
language English
format Article
sources DOAJ
author Claudia R. L. Cardoso
Gil F. Salles
spellingShingle Claudia R. L. Cardoso
Gil F. Salles
Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
International Journal of Molecular Sciences
arterial stiffness
type 2 diabetes
carotid-femoral pulse wave velocity
microvascular and macrovascular complications
author_facet Claudia R. L. Cardoso
Gil F. Salles
author_sort Claudia R. L. Cardoso
title Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
title_short Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
title_full Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
title_fullStr Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
title_full_unstemmed Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
title_sort aortic stiffness as a surrogate endpoint to micro- and macrovascular complications in patients with type 2 diabetes
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2016-12-01
description Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.
topic arterial stiffness
type 2 diabetes
carotid-femoral pulse wave velocity
microvascular and macrovascular complications
url http://www.mdpi.com/1422-0067/17/12/2044
work_keys_str_mv AT claudiarlcardoso aorticstiffnessasasurrogateendpointtomicroandmacrovascularcomplicationsinpatientswithtype2diabetes
AT gilfsalles aorticstiffnessasasurrogateendpointtomicroandmacrovascularcomplicationsinpatientswithtype2diabetes
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