Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes
Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2...
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doaj-ef3242f843e640809c7358d1dcb139772020-11-24T22:06:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-12-011712204410.3390/ijms17122044ijms17122044Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 DiabetesClaudia R. L. Cardoso0Gil F. Salles1Department of Internal Medicine, School of Medicine and University Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Rodolpho Rocco 255, Cidade Universitária, Rio de Janeiro-RJ 21941-901, BrazilDepartment of Internal Medicine, School of Medicine and University Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Rodolpho Rocco 255, Cidade Universitária, Rio de Janeiro-RJ 21941-901, BrazilIncreased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.http://www.mdpi.com/1422-0067/17/12/2044arterial stiffnesstype 2 diabetescarotid-femoral pulse wave velocitymicrovascular and macrovascular complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia R. L. Cardoso Gil F. Salles |
spellingShingle |
Claudia R. L. Cardoso Gil F. Salles Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes International Journal of Molecular Sciences arterial stiffness type 2 diabetes carotid-femoral pulse wave velocity microvascular and macrovascular complications |
author_facet |
Claudia R. L. Cardoso Gil F. Salles |
author_sort |
Claudia R. L. Cardoso |
title |
Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes |
title_short |
Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes |
title_full |
Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes |
title_fullStr |
Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes |
title_full_unstemmed |
Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes |
title_sort |
aortic stiffness as a surrogate endpoint to micro- and macrovascular complications in patients with type 2 diabetes |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-12-01 |
description |
Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management. |
topic |
arterial stiffness type 2 diabetes carotid-femoral pulse wave velocity microvascular and macrovascular complications |
url |
http://www.mdpi.com/1422-0067/17/12/2044 |
work_keys_str_mv |
AT claudiarlcardoso aorticstiffnessasasurrogateendpointtomicroandmacrovascularcomplicationsinpatientswithtype2diabetes AT gilfsalles aorticstiffnessasasurrogateendpointtomicroandmacrovascularcomplicationsinpatientswithtype2diabetes |
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