Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications
Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad...
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Series: | Contrast Media & Molecular Imaging |
Online Access: | http://dx.doi.org/10.1155/2018/2015237 |
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doaj-ef355ee4e933491f91280a6ef00672e82020-11-24T23:34:33ZengHindawi-WileyContrast Media & Molecular Imaging1555-43091555-43172018-01-01201810.1155/2018/20152372015237Targeted Optical Imaging Agents in Cancer: Focus on Clinical ApplicationsBishnu P. Joshi0Thomas D. Wang1Division of Gastroenterology, Department of Internal Medicine, School of Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 1722, Ann Arbor, MI 48109, USADivision of Gastroenterology, Department of Internal Medicine, School of Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 1722, Ann Arbor, MI 48109, USAMolecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad spectral range of light that spans from visible to near-infrared. Targeted ligands are being developed for improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, and antibody. Fluorescence labeling is used to provide high image contrast. This emerging methodology is clinically useful for early cancer detection by identifying and localizing suspicious lesions that may not otherwise be seen and serves as a guide for tissue biopsy and surgical resection. Visualizing molecular expression patterns may also be useful to determine the best choice of therapy and to monitor efficacy. A number of these imaging agents are overcoming key challenges for clinical translation and are being validated in vivo for a wide range of human cancers.http://dx.doi.org/10.1155/2018/2015237 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bishnu P. Joshi Thomas D. Wang |
spellingShingle |
Bishnu P. Joshi Thomas D. Wang Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications Contrast Media & Molecular Imaging |
author_facet |
Bishnu P. Joshi Thomas D. Wang |
author_sort |
Bishnu P. Joshi |
title |
Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications |
title_short |
Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications |
title_full |
Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications |
title_fullStr |
Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications |
title_full_unstemmed |
Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications |
title_sort |
targeted optical imaging agents in cancer: focus on clinical applications |
publisher |
Hindawi-Wiley |
series |
Contrast Media & Molecular Imaging |
issn |
1555-4309 1555-4317 |
publishDate |
2018-01-01 |
description |
Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad spectral range of light that spans from visible to near-infrared. Targeted ligands are being developed for improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, and antibody. Fluorescence labeling is used to provide high image contrast. This emerging methodology is clinically useful for early cancer detection by identifying and localizing suspicious lesions that may not otherwise be seen and serves as a guide for tissue biopsy and surgical resection. Visualizing molecular expression patterns may also be useful to determine the best choice of therapy and to monitor efficacy. A number of these imaging agents are overcoming key challenges for clinical translation and are being validated in vivo for a wide range of human cancers. |
url |
http://dx.doi.org/10.1155/2018/2015237 |
work_keys_str_mv |
AT bishnupjoshi targetedopticalimagingagentsincancerfocusonclinicalapplications AT thomasdwang targetedopticalimagingagentsincancerfocusonclinicalapplications |
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1725528901902401536 |