The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA
Termination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA.
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Nature Publishing Group
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14861 |
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doaj-ef394db5756b48a9bb4c2015dc21a1122021-05-11T07:53:06ZengNature Publishing GroupNature Communications2041-17232017-04-018111510.1038/ncomms14861The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNASina Wittmann0Max Renner1Beth R. Watts2Oliver Adams3Miles Huseyin4Carlo Baejen5Kamel El Omari6Cornelia Kilchert7Dong-Hyuk Heo8Tea Kecman9Patrick Cramer10Jonathan M. Grimes11Lidia Vasiljeva12Department of Biochemistry, University of OxfordDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of OxfordDepartment of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordDepartment of Molecular Biology, Max Planck Institute for Biophysical ChemistryDiamond Light Source Ltd, Harwell Science & Innovation CampusDepartment of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordDepartment of Molecular Biology, Max Planck Institute for Biophysical ChemistryDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of OxfordDepartment of Biochemistry, University of OxfordTermination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA.https://doi.org/10.1038/ncomms14861 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sina Wittmann Max Renner Beth R. Watts Oliver Adams Miles Huseyin Carlo Baejen Kamel El Omari Cornelia Kilchert Dong-Hyuk Heo Tea Kecman Patrick Cramer Jonathan M. Grimes Lidia Vasiljeva |
| spellingShingle |
Sina Wittmann Max Renner Beth R. Watts Oliver Adams Miles Huseyin Carlo Baejen Kamel El Omari Cornelia Kilchert Dong-Hyuk Heo Tea Kecman Patrick Cramer Jonathan M. Grimes Lidia Vasiljeva The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA Nature Communications |
| author_facet |
Sina Wittmann Max Renner Beth R. Watts Oliver Adams Miles Huseyin Carlo Baejen Kamel El Omari Cornelia Kilchert Dong-Hyuk Heo Tea Kecman Patrick Cramer Jonathan M. Grimes Lidia Vasiljeva |
| author_sort |
Sina Wittmann |
| title |
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA |
| title_short |
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA |
| title_full |
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA |
| title_fullStr |
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA |
| title_full_unstemmed |
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA |
| title_sort |
conserved protein seb1 drives transcription termination by binding rna polymerase ii and nascent rna |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-04-01 |
| description |
Termination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA. |
| url |
https://doi.org/10.1038/ncomms14861 |
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