Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population.
Heart failure affects 1-2% of the adult population worldwide and coronary artery disease (CAD) is the underlying etiology of heart failure in 70% of the patients. The pathway of apelin and its apelin receptor (APJ) was implicated in the pathogenesis of heart failure in animal models, but a similar r...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4438007?pdf=render |
id |
doaj-ef3da6056e7e4baf8a82fb7c38bed7ee |
---|---|
record_format |
Article |
spelling |
doaj-ef3da6056e7e4baf8a82fb7c38bed7ee2020-11-25T01:51:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012592610.1371/journal.pone.0125926Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population.Pengyun WangChengqi XuChuchu WangYanxia WuDan WangShanshan ChenYuanyuan ZhaoXiaojing WangSisi LiQin YangQiutang ZengXin TuYuhua LiaoQing K WangXiang ChengHeart failure affects 1-2% of the adult population worldwide and coronary artery disease (CAD) is the underlying etiology of heart failure in 70% of the patients. The pathway of apelin and its apelin receptor (APJ) was implicated in the pathogenesis of heart failure in animal models, but a similar role in humans is unknown. We studied a functional variant, rs9943582 (-154G/A), at the 5'-untranslated region, that was associated with decreased expression of the APJ receptor gene (APLNR) in a population consisting of 1,751 CAD cases and 1,022 controls. Variant rs9943582 was not associated with CAD, but among CAD patients, it showed significant association with left ventricular systolic dysfunction (431 CAD patients with left ventricular systolic dysfunction (LV ejection fraction or LVEF< 40%) versus 1,046 CAD patients without LV systolic dysfunction (LVEF>50%) (P-adj = 6.71 × 10(-5), OR = 1.43, 95% CI, 1.20-1.70). Moreover, rs9943582 also showed significant association with quantitative echocardiographic parameters, including left ventricular end-diastolic diameter (effect size: increased 1.67 ± 0.43 mm per risk allele A, P = 1.15 × 10(-4)), left atrial size (effect size: increased 2.12 ± 0.61 mm per risk allele A, P = 9.56 × 10(-4)) and LVEF (effect size: decreased 2.59 ± 0.32 percent per risk allele A, P = 7.50 × 10(-15)). Our findings demonstrate that allele A of rs9943582 was significantly associated with left ventricular systolic dysfunction, left ventricular end-diastolic diameter, the left atrial diameter and LVEF in the CAD population, which suggests an important role of the apelin/APJ system in the pathology of heart failure associated with ischemic heart disease.http://europepmc.org/articles/PMC4438007?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pengyun Wang Chengqi Xu Chuchu Wang Yanxia Wu Dan Wang Shanshan Chen Yuanyuan Zhao Xiaojing Wang Sisi Li Qin Yang Qiutang Zeng Xin Tu Yuhua Liao Qing K Wang Xiang Cheng |
spellingShingle |
Pengyun Wang Chengqi Xu Chuchu Wang Yanxia Wu Dan Wang Shanshan Chen Yuanyuan Zhao Xiaojing Wang Sisi Li Qin Yang Qiutang Zeng Xin Tu Yuhua Liao Qing K Wang Xiang Cheng Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. PLoS ONE |
author_facet |
Pengyun Wang Chengqi Xu Chuchu Wang Yanxia Wu Dan Wang Shanshan Chen Yuanyuan Zhao Xiaojing Wang Sisi Li Qin Yang Qiutang Zeng Xin Tu Yuhua Liao Qing K Wang Xiang Cheng |
author_sort |
Pengyun Wang |
title |
Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. |
title_short |
Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. |
title_full |
Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. |
title_fullStr |
Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. |
title_full_unstemmed |
Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population. |
title_sort |
association of snp rs9943582 in aplnr with left ventricle systolic dysfunction in patients with coronary artery disease in a chinese han geneid population. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Heart failure affects 1-2% of the adult population worldwide and coronary artery disease (CAD) is the underlying etiology of heart failure in 70% of the patients. The pathway of apelin and its apelin receptor (APJ) was implicated in the pathogenesis of heart failure in animal models, but a similar role in humans is unknown. We studied a functional variant, rs9943582 (-154G/A), at the 5'-untranslated region, that was associated with decreased expression of the APJ receptor gene (APLNR) in a population consisting of 1,751 CAD cases and 1,022 controls. Variant rs9943582 was not associated with CAD, but among CAD patients, it showed significant association with left ventricular systolic dysfunction (431 CAD patients with left ventricular systolic dysfunction (LV ejection fraction or LVEF< 40%) versus 1,046 CAD patients without LV systolic dysfunction (LVEF>50%) (P-adj = 6.71 × 10(-5), OR = 1.43, 95% CI, 1.20-1.70). Moreover, rs9943582 also showed significant association with quantitative echocardiographic parameters, including left ventricular end-diastolic diameter (effect size: increased 1.67 ± 0.43 mm per risk allele A, P = 1.15 × 10(-4)), left atrial size (effect size: increased 2.12 ± 0.61 mm per risk allele A, P = 9.56 × 10(-4)) and LVEF (effect size: decreased 2.59 ± 0.32 percent per risk allele A, P = 7.50 × 10(-15)). Our findings demonstrate that allele A of rs9943582 was significantly associated with left ventricular systolic dysfunction, left ventricular end-diastolic diameter, the left atrial diameter and LVEF in the CAD population, which suggests an important role of the apelin/APJ system in the pathology of heart failure associated with ischemic heart disease. |
url |
http://europepmc.org/articles/PMC4438007?pdf=render |
work_keys_str_mv |
AT pengyunwang associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT chengqixu associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT chuchuwang associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT yanxiawu associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT danwang associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT shanshanchen associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT yuanyuanzhao associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT xiaojingwang associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT sisili associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT qinyang associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT qiutangzeng associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT xintu associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT yuhualiao associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT qingkwang associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation AT xiangcheng associationofsnprs9943582inaplnrwithleftventriclesystolicdysfunctioninpatientswithcoronaryarterydiseaseinachinesehangeneidpopulation |
_version_ |
1724998228973191168 |