Biomarkers profile of oral squamous cell carcinoma

• Main Authors: Catalina RADULESCU, Cosmin TOTAN, Marina IMRE, Alexandra TOTAN, Radu RADULESCU, Oana Elena AMZA, Daniela MIRICESCU, Iulia-Ioana STANESCU, Maria GREABU
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2020-09-01
• Series: Romanian Journal of Medical Practice
• Subjects: oxidative stress; biomarker; carcinoma squamous cell; oral cavity; oxsr1; mmp-9
• Online Access: https://rjmp.com.ro/articles/2020.3/RJMP_2020_3_Art-08.pdf

More than 95% of oral cancers are represented by squamous cell carcinomas (OSCC). Despite the serious progress concerning the oral cancer treatment made in the last decade, the OSCC prognosis remains poor. Currently, the OSCC detection and diagnosis is mainly based on clinical oral examination combined with biopsy for a histopathological examination if a suspect area is detected. Our study has included 20 patients (12 females and 8 males) diagnosed with OSCC. TAC, OXSR1 and MMP-9 were measured in the tumoral cells lysates by ELISA. Our results revealed that the MMP-9 levels were significantly and negatively correlated with OXSR1 levels. Also, our study results illustrated a significant positive correlation of TAC with OXSR1. In conclusion, corroborating our findings with literature reports, we can outline that OXSR1 and MMP-9, together, possibly, with TAC, could be regarded as new steps in order to elaborate diagnostic tools for early detection OSCC.