The Rise of Non-Tuberculosis Mycobacterial Lung Disease
The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally. These lesser known “cousins” of Mycobacterium tuberculosis (TB) were once thought to be harmless environmental saprophytics and only dangerous to individuals with defective lun...
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doaj-ef45c5bca634442f8af08ae637843df82020-11-25T02:36:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-03-011110.3389/fimmu.2020.00303507325The Rise of Non-Tuberculosis Mycobacterial Lung DiseaseChampa N. Ratnatunga0Champa N. Ratnatunga1Champa N. Ratnatunga2Champa N. Ratnatunga3Viviana P. Lutzky4Andreas Kupz5Andreas Kupz6Denise L. Doolan7Denise L. Doolan8David W. Reid9Matthew Field10Matthew Field11Scott C. Bell12Rachel M. Thomson13John J. Miles14John J. Miles15John J. Miles16The Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Molecular Therapeutics, James Cook University, Cairns, QLD, AustraliaFaculty of Medicine, University of Queensland, Brisbane, QLD, AustraliaImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaThe Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Molecular Therapeutics, James Cook University, Cairns, QLD, AustraliaThe Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Molecular Therapeutics, James Cook University, Cairns, QLD, AustraliaImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaThe Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Tropical Bioinformatics and Molecular Biology, James Cook University, Cairns, QLD, AustraliaImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaImmunology Department, Gallipoli Medical Research Institute, Brisbane, QLD, AustraliaThe Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Molecular Therapeutics, James Cook University, Cairns, QLD, AustraliaCentre for Tropical Bioinformatics and Molecular Biology, James Cook University, Cairns, QLD, AustraliaThe incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally. These lesser known “cousins” of Mycobacterium tuberculosis (TB) were once thought to be harmless environmental saprophytics and only dangerous to individuals with defective lung structure or the immunosuppressed. However, NTM are now commonly infecting seemingly immune competent children and adults at increasing rates through pulmonary infection. This is of concern as the pathology of NTM is difficult to treat. Indeed, NTM have become extremely antibiotic resistant, and now have been found to be internationally dispersed through person-to-person contact. The reasons behind this NTM increase are only beginning to be elucidated. Solutions to the problem are needed given NTM disease is more common in the tropics. Importantly, 40% of the world's population live in the tropics and due to climate change, the Tropics are expanding which will increase NTM infection regions. This review catalogs the global and economic disease burden, at risk populations, treatment options, host-bacterial interaction, immune dynamics, recent developments and research priorities for NTM disease.https://www.frontiersin.org/article/10.3389/fimmu.2020.00303/fullNon-tuberculous mycobacteriapulmonary infectionmycobacteriaimmunologymycobacteria pathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Champa N. Ratnatunga Champa N. Ratnatunga Champa N. Ratnatunga Champa N. Ratnatunga Viviana P. Lutzky Andreas Kupz Andreas Kupz Denise L. Doolan Denise L. Doolan David W. Reid Matthew Field Matthew Field Scott C. Bell Rachel M. Thomson John J. Miles John J. Miles John J. Miles |
spellingShingle |
Champa N. Ratnatunga Champa N. Ratnatunga Champa N. Ratnatunga Champa N. Ratnatunga Viviana P. Lutzky Andreas Kupz Andreas Kupz Denise L. Doolan Denise L. Doolan David W. Reid Matthew Field Matthew Field Scott C. Bell Rachel M. Thomson John J. Miles John J. Miles John J. Miles The Rise of Non-Tuberculosis Mycobacterial Lung Disease Frontiers in Immunology Non-tuberculous mycobacteria pulmonary infection mycobacteria immunology mycobacteria pathology |
author_facet |
Champa N. Ratnatunga Champa N. Ratnatunga Champa N. Ratnatunga Champa N. Ratnatunga Viviana P. Lutzky Andreas Kupz Andreas Kupz Denise L. Doolan Denise L. Doolan David W. Reid Matthew Field Matthew Field Scott C. Bell Rachel M. Thomson John J. Miles John J. Miles John J. Miles |
author_sort |
Champa N. Ratnatunga |
title |
The Rise of Non-Tuberculosis Mycobacterial Lung Disease |
title_short |
The Rise of Non-Tuberculosis Mycobacterial Lung Disease |
title_full |
The Rise of Non-Tuberculosis Mycobacterial Lung Disease |
title_fullStr |
The Rise of Non-Tuberculosis Mycobacterial Lung Disease |
title_full_unstemmed |
The Rise of Non-Tuberculosis Mycobacterial Lung Disease |
title_sort |
rise of non-tuberculosis mycobacterial lung disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-03-01 |
description |
The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally. These lesser known “cousins” of Mycobacterium tuberculosis (TB) were once thought to be harmless environmental saprophytics and only dangerous to individuals with defective lung structure or the immunosuppressed. However, NTM are now commonly infecting seemingly immune competent children and adults at increasing rates through pulmonary infection. This is of concern as the pathology of NTM is difficult to treat. Indeed, NTM have become extremely antibiotic resistant, and now have been found to be internationally dispersed through person-to-person contact. The reasons behind this NTM increase are only beginning to be elucidated. Solutions to the problem are needed given NTM disease is more common in the tropics. Importantly, 40% of the world's population live in the tropics and due to climate change, the Tropics are expanding which will increase NTM infection regions. This review catalogs the global and economic disease burden, at risk populations, treatment options, host-bacterial interaction, immune dynamics, recent developments and research priorities for NTM disease. |
topic |
Non-tuberculous mycobacteria pulmonary infection mycobacteria immunology mycobacteria pathology |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.00303/full |
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