Intraspecies prion transmission results in selection of sheep scrapie strains.
BACKGROUND: Sheep scrapie is caused by multiple prion strains, which have been classified on the basis of their biological characteristics in inbred mice. The heterogeneity of natural scrapie prions in individual sheep and in sheep flocks has not been clearly defined. METHODOLOGY/PRINCIPAL FINDINGS:...
Main Authors: | Takashi Yokoyama, Kentaro Masujin, Mary Jo Schmerr, Yujing Shu, Hiroyuki Okada, Yoshifumi Iwamaru, Morikazu Imamura, Yuichi Matsuura, Yuichi Murayama, Shirou Mohri |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2982847?pdf=render |
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