The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial
Background: Deficiency of vitamin D, an anti-inflammatory micronutrient with some favorable effects on lipid profiles, has been found to be highly prevalent in adolescents. We aimed to investigate the effect of a school-based vitamin D supplementation regimen on the correction of vitamin D deficienc...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-04-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/12/5/1213 |
id |
doaj-ef51583b194f4884a077ac14c3f223b5 |
---|---|
record_format |
Article |
spelling |
doaj-ef51583b194f4884a077ac14c3f223b52020-11-25T02:59:50ZengMDPI AGNutrients2072-66432020-04-01121213121310.3390/nu12051213The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled TrialAmirhossein Yarparvar0Ibrahim Elmadfa1Abolghasem Djazayery2Zahra Abdollahi3Forouzan Salehi4Ramin Heshmat5School of Nutrition, University of Vienna, 1090 Vienna, AustriaSchool of Nutrition, University of Vienna, 1090 Vienna, AustriaSchool of Nutrition and Dietetics, Tehran University of Medical Science, Tehran 14155/6117, IranNutrition Department of the Ministry of health and Medical Education, Tehran 1467664961, IranDeputy Director of Family Health Department of the Ministry of Health and Medical Education, Tehran 1467664961, IranRamin Heshmat, Tehran University of Medical Sciences, Tehran 141675395, IranBackground: Deficiency of vitamin D, an anti-inflammatory micronutrient with some favorable effects on lipid profiles, has been found to be highly prevalent in adolescents. We aimed to investigate the effect of a school-based vitamin D supplementation regimen on the correction of vitamin D deficiency as well as lipid and inflammatory profiles of healthy adolescent boys. Methods: In this randomized single-blind placebo-controlled trial, seventy-one healthy adolescent boys (age 17 years old) were recruited from one high school in Tehran, Iran, and randomly assigned to two groups. The supplement group received vitamin D pearls at a dose of 50,000 IU monthly for 6 months, this dose is indeed defined by the Ministry of Health in Iran for a potential national school-based vitamin D supplementation program. The other group was given placebo pearls for the same duration. Before and after the treatment, the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), retinol, lead (Pb), the lipid profile and the inflammatory biomarkers were measured and compared. Results: Between-groups statistical analysis showed that a dose (50,000 IU/month) vitamin D significantly increased the serum levels of 25-hydroxyvitamin D (25 (OH) D) (<i>p</i> < 0.001) and decreased serum levels of PTH (<i>p</i> = 0.003). No significant change was observed in serum levels of retinol and Pb. Between-group analysis revealed that the serum levels of TG (P = 0.001) decreased while an increase in serum levels of HDL (<i>p</i> = 0.021) was observed (<i>p </i>< 0.05). Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (<i>p </i>< 0.05). Conclusion: A supplementation regimen of (50,000 IU/month) vitamin D in a context with high rates of vitamin deficiency has shown positive impacts on the serum vitamin D, lipid profile and inflammatory biomarkers in healthy adolescent boys.https://www.mdpi.com/2072-6643/12/5/1213vitamin D supplementationadolescentinflammationlipid profilePTH |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amirhossein Yarparvar Ibrahim Elmadfa Abolghasem Djazayery Zahra Abdollahi Forouzan Salehi Ramin Heshmat |
spellingShingle |
Amirhossein Yarparvar Ibrahim Elmadfa Abolghasem Djazayery Zahra Abdollahi Forouzan Salehi Ramin Heshmat The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial Nutrients vitamin D supplementation adolescent inflammation lipid profile PTH |
author_facet |
Amirhossein Yarparvar Ibrahim Elmadfa Abolghasem Djazayery Zahra Abdollahi Forouzan Salehi Ramin Heshmat |
author_sort |
Amirhossein Yarparvar |
title |
The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial |
title_short |
The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial |
title_full |
The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial |
title_fullStr |
The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial |
title_full_unstemmed |
The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial |
title_sort |
effects of vitamin d supplementation on lipid and inflammatory profile of healthy adolescent boys: a randomized controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-04-01 |
description |
Background: Deficiency of vitamin D, an anti-inflammatory micronutrient with some favorable effects on lipid profiles, has been found to be highly prevalent in adolescents. We aimed to investigate the effect of a school-based vitamin D supplementation regimen on the correction of vitamin D deficiency as well as lipid and inflammatory profiles of healthy adolescent boys. Methods: In this randomized single-blind placebo-controlled trial, seventy-one healthy adolescent boys (age 17 years old) were recruited from one high school in Tehran, Iran, and randomly assigned to two groups. The supplement group received vitamin D pearls at a dose of 50,000 IU monthly for 6 months, this dose is indeed defined by the Ministry of Health in Iran for a potential national school-based vitamin D supplementation program. The other group was given placebo pearls for the same duration. Before and after the treatment, the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), retinol, lead (Pb), the lipid profile and the inflammatory biomarkers were measured and compared. Results: Between-groups statistical analysis showed that a dose (50,000 IU/month) vitamin D significantly increased the serum levels of 25-hydroxyvitamin D (25 (OH) D) (<i>p</i> < 0.001) and decreased serum levels of PTH (<i>p</i> = 0.003). No significant change was observed in serum levels of retinol and Pb. Between-group analysis revealed that the serum levels of TG (P = 0.001) decreased while an increase in serum levels of HDL (<i>p</i> = 0.021) was observed (<i>p </i>< 0.05). Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (<i>p </i>< 0.05). Conclusion: A supplementation regimen of (50,000 IU/month) vitamin D in a context with high rates of vitamin deficiency has shown positive impacts on the serum vitamin D, lipid profile and inflammatory biomarkers in healthy adolescent boys. |
topic |
vitamin D supplementation adolescent inflammation lipid profile PTH |
url |
https://www.mdpi.com/2072-6643/12/5/1213 |
work_keys_str_mv |
AT amirhosseinyarparvar theeffectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT ibrahimelmadfa theeffectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT abolghasemdjazayery theeffectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT zahraabdollahi theeffectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT forouzansalehi theeffectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT raminheshmat theeffectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT amirhosseinyarparvar effectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT ibrahimelmadfa effectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT abolghasemdjazayery effectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT zahraabdollahi effectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT forouzansalehi effectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial AT raminheshmat effectsofvitamindsupplementationonlipidandinflammatoryprofileofhealthyadolescentboysarandomizedcontrolledtrial |
_version_ |
1724700870942130176 |