Combination treatment for ventilator-associated pneumonia in neonatal infants

• Main Authors: M. V. Kushnareva, A. Yu. Gerasimov, G. M. Dementieva, E. S. Keshishian, T. S. Okuneva
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2016-04-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: newborn infants; nosocomial infection; ventilator-associated pneumonia; etiology; linezolid; treatmen
• Online Access: https://www.ped-perinatology.ru/jour/article/view/310

The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants.