Combination treatment for ventilator-associated pneumonia in neonatal infants
The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens w...
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Ltd. “The National Academy of Pediatric Science and Innovation”
2016-04-01
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Online Access: | https://www.ped-perinatology.ru/jour/article/view/310 |
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doaj-ef53a8bdc49d4f5f9e697387aaaecbff2021-07-28T16:27:45ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282016-04-01612929910.21508/1027-4065-2016-61-2-92-99301Combination treatment for ventilator-associated pneumonia in neonatal infantsM. V. Kushnareva0A. Yu. Gerasimov1G. M. Dementieva2E. S. Keshishian3T. S. Okuneva4Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationMaternal Hospital Fifteen, City Clinical Hospital ThirteenAcademician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationAcademician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationAcademician Yu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian FederationThe paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants.https://www.ped-perinatology.ru/jour/article/view/310newborn infantsnosocomial infectionventilator-associated pneumoniaetiologylinezolidtreatmen |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
M. V. Kushnareva A. Yu. Gerasimov G. M. Dementieva E. S. Keshishian T. S. Okuneva |
spellingShingle |
M. V. Kushnareva A. Yu. Gerasimov G. M. Dementieva E. S. Keshishian T. S. Okuneva Combination treatment for ventilator-associated pneumonia in neonatal infants Rossijskij Vestnik Perinatologii i Pediatrii newborn infants nosocomial infection ventilator-associated pneumonia etiology linezolid treatmen |
author_facet |
M. V. Kushnareva A. Yu. Gerasimov G. M. Dementieva E. S. Keshishian T. S. Okuneva |
author_sort |
M. V. Kushnareva |
title |
Combination treatment for ventilator-associated pneumonia in neonatal infants |
title_short |
Combination treatment for ventilator-associated pneumonia in neonatal infants |
title_full |
Combination treatment for ventilator-associated pneumonia in neonatal infants |
title_fullStr |
Combination treatment for ventilator-associated pneumonia in neonatal infants |
title_full_unstemmed |
Combination treatment for ventilator-associated pneumonia in neonatal infants |
title_sort |
combination treatment for ventilator-associated pneumonia in neonatal infants |
publisher |
Ltd. “The National Academy of Pediatric Science and Innovation” |
series |
Rossijskij Vestnik Perinatologii i Pediatrii |
issn |
1027-4065 2500-2228 |
publishDate |
2016-04-01 |
description |
The paper deals with an investigation of the clinical and microbiological efficiency of combination treatment in 63 term and preterm neonates with ventilator-associated pneumonia caused by gram-positive cocci or their associations with gram-negative bacteria. All strains of gram-positive pathogens were susceptible to linezolid (its minimal inhibitory concentration was ≤ 4 µg/ml). The drug was used in combination with β-lactam antibiotics or aminoglycosides. All the infants displayed positive microbiological changes. Clinical effectiveness was noted in 95% of the newborn infants. There was secondary infection with gram-negative microorganisms in 25 cases and that with Enterococcus faecalis autostrains in 2 preterm infants. |
topic |
newborn infants nosocomial infection ventilator-associated pneumonia etiology linezolid treatmen |
url |
https://www.ped-perinatology.ru/jour/article/view/310 |
work_keys_str_mv |
AT mvkushnareva combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT ayugerasimov combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT gmdementieva combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT eskeshishian combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants AT tsokuneva combinationtreatmentforventilatorassociatedpneumoniainneonatalinfants |
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1721266464944553984 |