mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy

mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy

Abstract Background Neurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage. Autophagy dysregulation is considered a potential cause of neuronal cell loss, however underlying mechanisms remain unclear. The mechanistic ta...

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Bibliographic Details
Main Authors: Sanjar Batirovich Madrakhimov, Jin Young Yang, Jin Ha Kim, Jung Woo Han, Tae Kwann Park
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
Diabetic retinopathy
Neurodegeneration
Autophagy
Apoptosis
The mechanistic target of rapamycin (mTOR)
Online Access:https://doi.org/10.1186/s12964-020-00698-4

Internet

https://doi.org/10.1186/s12964-020-00698-4

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