Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease
Objective. Health economic expertise of pramipexole extended release monotherapy at early stages of Parkinson’s disease. Methods. An economic model was developed based on clinical studies to derive comparative information on the effectiveness, utility and direct medical costs of antiparkinsonian tre...
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Izdatelstvo OKI
2018-05-01
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Series: | Качественная клиническая практика |
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Online Access: | https://www.clinvest.ru/jour/article/view/8 |
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doaj-ef5de7d32a52495cbb51612be9b6e3402020-11-25T03:04:39ZrusIzdatelstvo OKIКачественная клиническая практика2588-05192618-84732018-05-010153648Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s diseaseD. Yu. Belousov0E. V. Afanasyeva1LLC "Center for Pharmacoeconomics Research", MoscowLLC "Center for Pharmacoeconomics Research", MoscowObjective. Health economic expertise of pramipexole extended release monotherapy at early stages of Parkinson’s disease. Methods. An economic model was developed based on clinical studies to derive comparative information on the effectiveness, utility and direct medical costs of antiparkinsonian treatment strategies over a year period. Cost-effectiveness, cost-utility and budget impact of comparative therapies were assessed. Results. Mirapex® extended release (ER) has the lowest cost-effectiveness ratio (31 499 rub. per a patient a year responded to antiparkinsonian therapy) and the lowest cost-utility ratio (2 562 rub. for decrease of degree of abnormalities of daily activities and motive abnormalities per a point of UPDRS scale). Budget impact analysis demonstrated that pramipexole ER monotherapy resulted in cost saving of 6 499 rub. (20 %) compared to Pronoran®, 26 918 rub. (51%) compared to Requip Modutab® and 24 966 rub. (49%) compared to Azilect® per a year of therapy. Mirapex® ER was the dominant strategy demonstrating higher effectiveness at lower costs in Parkinson’s disease treatment.https://www.clinvest.ru/jour/article/view/8фармакоэкономикаанализ эффективности затратанализ полезности затратанализ влияния на бюджетболезнь паркинсонапрамипексол пролонгированного действияpharmacoeconomicsoutcome researchcost-effectiveness analysiscost-utility analysisparkinson’s diseasepramipexole extended release |
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DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
D. Yu. Belousov E. V. Afanasyeva |
spellingShingle |
D. Yu. Belousov E. V. Afanasyeva Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease Качественная клиническая практика фармакоэкономика анализ эффективности затрат анализ полезности затрат анализ влияния на бюджет болезнь паркинсона прамипексол пролонгированного действия pharmacoeconomics outcome research cost-effectiveness analysis cost-utility analysis parkinson’s disease pramipexole extended release |
author_facet |
D. Yu. Belousov E. V. Afanasyeva |
author_sort |
D. Yu. Belousov |
title |
Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease |
title_short |
Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease |
title_full |
Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease |
title_fullStr |
Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease |
title_full_unstemmed |
Pharmacoeconomic evaluation of pramipexole extended release monotherapy in early Parkinson’s disease |
title_sort |
pharmacoeconomic evaluation of pramipexole extended release monotherapy in early parkinson’s disease |
publisher |
Izdatelstvo OKI |
series |
Качественная клиническая практика |
issn |
2588-0519 2618-8473 |
publishDate |
2018-05-01 |
description |
Objective. Health economic expertise of pramipexole extended release monotherapy at early stages of Parkinson’s disease. Methods. An economic model was developed based on clinical studies to derive comparative information on the effectiveness, utility and direct medical costs of antiparkinsonian treatment strategies over a year period. Cost-effectiveness, cost-utility and budget impact of comparative therapies were assessed. Results. Mirapex® extended release (ER) has the lowest cost-effectiveness ratio (31 499 rub. per a patient a year responded to antiparkinsonian therapy) and the lowest cost-utility ratio (2 562 rub. for decrease of degree of abnormalities of daily activities and motive abnormalities per a point of UPDRS scale). Budget impact analysis demonstrated that pramipexole ER monotherapy resulted in cost saving of 6 499 rub. (20 %) compared to Pronoran®, 26 918 rub. (51%) compared to Requip Modutab® and 24 966 rub. (49%) compared to Azilect® per a year of therapy. Mirapex® ER was the dominant strategy demonstrating higher effectiveness at lower costs in Parkinson’s disease treatment. |
topic |
фармакоэкономика анализ эффективности затрат анализ полезности затрат анализ влияния на бюджет болезнь паркинсона прамипексол пролонгированного действия pharmacoeconomics outcome research cost-effectiveness analysis cost-utility analysis parkinson’s disease pramipexole extended release |
url |
https://www.clinvest.ru/jour/article/view/8 |
work_keys_str_mv |
AT dyubelousov pharmacoeconomicevaluationofpramipexoleextendedreleasemonotherapyinearlyparkinsonsdisease AT evafanasyeva pharmacoeconomicevaluationofpramipexoleextendedreleasemonotherapyinearlyparkinsonsdisease |
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1724680599402184704 |