Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation.
The role of ribosomal protein S6 (rpS6) phosphorylation in mRNA translation remains poorly understood. Here, we reveal a potential role in modulating the translation rate of chemokine (C-X-C motif) ligand 8 (CXCL8 or Interleukin 8, IL8). We observed that more CXCL8 protein was being secreted from le...
Main Authors: | Zhiwei Ang, Ricky Abdi Gunawan Koean, Jun Zhi Er, Li Ting Lee, John Kit Chung Tam, Huili Guo, Jeak Ling Ding |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-04-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC6476525?pdf=render |
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