Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders.
Perinatal asphyxia, a naturally and commonly occurring risk factor in birthing, represents one of the major causes of neonatal encephalopathy with long term consequences for infants. Here, degraded spectral and temporal responses to sounds were recorded from neurons in the primary auditory cortex (A...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-12-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3009724?pdf=render |
id |
doaj-ef67513179e6431f9b78488cf76d89dc |
---|---|
record_format |
Article |
spelling |
doaj-ef67513179e6431f9b78488cf76d89dc2020-11-24T22:17:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-12-01512e1532610.1371/journal.pone.0015326Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders.Fabrizio StrataIvilin P StoianovEtienne de Villers-SidaniBen BonhamTiziana MartoneTal KenetEdward F ChangVincenzo VincentiMichael M MerzenichPerinatal asphyxia, a naturally and commonly occurring risk factor in birthing, represents one of the major causes of neonatal encephalopathy with long term consequences for infants. Here, degraded spectral and temporal responses to sounds were recorded from neurons in the primary auditory cortex (A1) of adult rats exposed to asphyxia at birth. Response onset latencies and durations were increased. Response amplitudes were reduced. Tuning curves were broader. Degraded successive-stimulus masking inhibitory mechanisms were associated with a reduced capability of neurons to follow higher-rate repetitive stimuli. The architecture of peripheral inner ear sensory epithelium was preserved, suggesting that recorded abnormalities can be of central origin. Some implications of these findings for the genesis of language perception deficits or for impaired language expression recorded in developmental disorders, such as autism spectrum disorders, contributed to by perinatal asphyxia, are discussed.http://europepmc.org/articles/PMC3009724?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabrizio Strata Ivilin P Stoianov Etienne de Villers-Sidani Ben Bonham Tiziana Martone Tal Kenet Edward F Chang Vincenzo Vincenti Michael M Merzenich |
spellingShingle |
Fabrizio Strata Ivilin P Stoianov Etienne de Villers-Sidani Ben Bonham Tiziana Martone Tal Kenet Edward F Chang Vincenzo Vincenti Michael M Merzenich Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. PLoS ONE |
author_facet |
Fabrizio Strata Ivilin P Stoianov Etienne de Villers-Sidani Ben Bonham Tiziana Martone Tal Kenet Edward F Chang Vincenzo Vincenti Michael M Merzenich |
author_sort |
Fabrizio Strata |
title |
Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. |
title_short |
Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. |
title_full |
Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. |
title_fullStr |
Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. |
title_full_unstemmed |
Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. |
title_sort |
perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disorders. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2010-12-01 |
description |
Perinatal asphyxia, a naturally and commonly occurring risk factor in birthing, represents one of the major causes of neonatal encephalopathy with long term consequences for infants. Here, degraded spectral and temporal responses to sounds were recorded from neurons in the primary auditory cortex (A1) of adult rats exposed to asphyxia at birth. Response onset latencies and durations were increased. Response amplitudes were reduced. Tuning curves were broader. Degraded successive-stimulus masking inhibitory mechanisms were associated with a reduced capability of neurons to follow higher-rate repetitive stimuli. The architecture of peripheral inner ear sensory epithelium was preserved, suggesting that recorded abnormalities can be of central origin. Some implications of these findings for the genesis of language perception deficits or for impaired language expression recorded in developmental disorders, such as autism spectrum disorders, contributed to by perinatal asphyxia, are discussed. |
url |
http://europepmc.org/articles/PMC3009724?pdf=render |
work_keys_str_mv |
AT fabriziostrata perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT ivilinpstoianov perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT etiennedevillerssidani perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT benbonham perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT tizianamartone perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT talkenet perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT edwardfchang perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT vincenzovincenti perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders AT michaelmmerzenich perinatalasphyxiaaffectsratauditoryprocessingimplicationsforauditoryperceptualimpairmentsinneurodevelopmentaldisorders |
_version_ |
1725786591609225216 |