Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NS...
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doaj-ef72084b97fb48cc87e1284b6426f1142020-11-25T00:46:08ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-11-011811231210.3390/ijms18112312ijms18112312Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in NeurogenesisTadahiro Numakawa0Haruki Odaka1Naoki Adachi2Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-8555, JapanDepartment of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-8555, JapanDepartment of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda City, Hyogo 662-8501, JapanAltered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder. Furthermore, studies including ours have demonstrated functional interactions between neurotrophic factors and GCs in neural events, including neurogenesis. In this review, we show and discuss relationships among the behaviors of NSCs/NPCs, BDNF, and GCs.https://www.mdpi.com/1422-0067/18/11/2312BDNFneurogenesisneural stem cellsglucocorticoidsintracellular signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tadahiro Numakawa Haruki Odaka Naoki Adachi |
spellingShingle |
Tadahiro Numakawa Haruki Odaka Naoki Adachi Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis International Journal of Molecular Sciences BDNF neurogenesis neural stem cells glucocorticoids intracellular signaling |
author_facet |
Tadahiro Numakawa Haruki Odaka Naoki Adachi |
author_sort |
Tadahiro Numakawa |
title |
Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis |
title_short |
Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis |
title_full |
Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis |
title_fullStr |
Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis |
title_full_unstemmed |
Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis |
title_sort |
actions of brain-derived neurotrophic factor and glucocorticoid stress in neurogenesis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-11-01 |
description |
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder. Furthermore, studies including ours have demonstrated functional interactions between neurotrophic factors and GCs in neural events, including neurogenesis. In this review, we show and discuss relationships among the behaviors of NSCs/NPCs, BDNF, and GCs. |
topic |
BDNF neurogenesis neural stem cells glucocorticoids intracellular signaling |
url |
https://www.mdpi.com/1422-0067/18/11/2312 |
work_keys_str_mv |
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