Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation
Background and Aim: The study was performed to confirm the clinical characteristics and peripheral blood level of natural killer (NK) cells as a diagnostic index in women with recurrent spontaneous abortion (RSA) comparing with normal pregnant women. Materials and Methods: Consultation with all pati...
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Wolters Kluwer Medknow Publications
2019-01-01
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Online Access: | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=191;epage=194;aulast=Kim |
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doaj-ef76aa04d6924291b2f860ed4f48bcb02020-11-25T01:51:06ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482019-01-017219119410.4103/amhs.amhs_23_19Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestationSung-Guk KimMi-Yong PaekIl Gyong KoBackground and Aim: The study was performed to confirm the clinical characteristics and peripheral blood level of natural killer (NK) cells as a diagnostic index in women with recurrent spontaneous abortion (RSA) comparing with normal pregnant women. Materials and Methods: Consultation with all patients was conducted to obtain the number and timing of previous miscarriages and signs and symptoms of abortion progress. Assessment of peripheral blood NK cell level was performed by flowcytometric analyses. Results: Women with RSA have brown-colored vaginal bleeding and history of more than three consecutive miscarriage, while the percentage of peripheral blood NK cell within blood lymphocytes was more than 18.1%. Conclusion: In the current study, RSA patients (6–12 weeks') showed significantly higher level of peripheral blood NK cells (>18.1%) compared to that of normal gravidas. Further studies are required to clarify the precise mechanism how NK cells affect the progression of healthy pregnancy and investigate clinical evidence whether therapies to lower the level of NK cells can decrease the rate of RSA.http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=191;epage=194;aulast=Kim6–12 weeksconsecutive miscarriagenatural killer cellperipheral bloodrecurrent spontaneous abortion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sung-Guk Kim Mi-Yong Paek Il Gyong Ko |
spellingShingle |
Sung-Guk Kim Mi-Yong Paek Il Gyong Ko Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation Archives of Medicine and Health Sciences 6–12 weeks consecutive miscarriage natural killer cell peripheral blood recurrent spontaneous abortion |
author_facet |
Sung-Guk Kim Mi-Yong Paek Il Gyong Ko |
author_sort |
Sung-Guk Kim |
title |
Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation |
title_short |
Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation |
title_full |
Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation |
title_fullStr |
Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation |
title_full_unstemmed |
Peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation |
title_sort |
peripheral blood level of natural killer cells in pregnant women with recurrent spontaneous abortion during the 6–12 weeks gestation |
publisher |
Wolters Kluwer Medknow Publications |
series |
Archives of Medicine and Health Sciences |
issn |
2321-4848 |
publishDate |
2019-01-01 |
description |
Background and Aim: The study was performed to confirm the clinical characteristics and peripheral blood level of natural killer (NK) cells as a diagnostic index in women with recurrent spontaneous abortion (RSA) comparing with normal pregnant women. Materials and Methods: Consultation with all patients was conducted to obtain the number and timing of previous miscarriages and signs and symptoms of abortion progress. Assessment of peripheral blood NK cell level was performed by flowcytometric analyses. Results: Women with RSA have brown-colored vaginal bleeding and history of more than three consecutive miscarriage, while the percentage of peripheral blood NK cell within blood lymphocytes was more than 18.1%. Conclusion: In the current study, RSA patients (6–12 weeks') showed significantly higher level of peripheral blood NK cells (>18.1%) compared to that of normal gravidas. Further studies are required to clarify the precise mechanism how NK cells affect the progression of healthy pregnancy and investigate clinical evidence whether therapies to lower the level of NK cells can decrease the rate of RSA. |
topic |
6–12 weeks consecutive miscarriage natural killer cell peripheral blood recurrent spontaneous abortion |
url |
http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2019;volume=7;issue=2;spage=191;epage=194;aulast=Kim |
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