The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites o...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3665554?pdf=render |
id |
doaj-ef793f4b4a6741ac9ef766d883c54426 |
---|---|
record_format |
Article |
spelling |
doaj-ef793f4b4a6741ac9ef766d883c544262020-11-25T02:15:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6497310.1371/journal.pone.0064973The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.Yu XuHongxia MaHongping YuZhensheng LiuLi-E WangDongfeng TanRamya MuddasaniVictoria LuJaffer A AjaniYanong WangQingyi WeiTNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3'UTR of TNFAIP2 and gastric cancer risk in a US population.We conducted a case-control study of 301 gastric cancer patients and 313 cancer-free controls frequency-matched by age, sex and ethnicity. We genotyped four selected TNFAIP2 SNPs (rs8126 T>C, rs710100 G>A, rs1052912 G>A and rs1052823 G>T) and used the logistic regression analysis to assess associations of these SNPs with cancer risk.The rs8126 CC genotype was associated with a significantly elevated risk of gastric cancer (adjusted OR = 2.00, 95% CI = 1.09-3.64 and P = 0.024), compared with the combined rs8126 TT+TC genotypes, particularly in current drinkers. However, none of other TNFAIP2 SNPs was associated with risk of gastric cancer.Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies.http://europepmc.org/articles/PMC3665554?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Xu Hongxia Ma Hongping Yu Zhensheng Liu Li-E Wang Dongfeng Tan Ramya Muddasani Victoria Lu Jaffer A Ajani Yanong Wang Qingyi Wei |
spellingShingle |
Yu Xu Hongxia Ma Hongping Yu Zhensheng Liu Li-E Wang Dongfeng Tan Ramya Muddasani Victoria Lu Jaffer A Ajani Yanong Wang Qingyi Wei The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. PLoS ONE |
author_facet |
Yu Xu Hongxia Ma Hongping Yu Zhensheng Liu Li-E Wang Dongfeng Tan Ramya Muddasani Victoria Lu Jaffer A Ajani Yanong Wang Qingyi Wei |
author_sort |
Yu Xu |
title |
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. |
title_short |
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. |
title_full |
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. |
title_fullStr |
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. |
title_full_unstemmed |
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. |
title_sort |
mir-184 binding-site rs8126 t>c polymorphism in tnfaip2 is associated with risk of gastric cancer. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3'UTR of TNFAIP2 and gastric cancer risk in a US population.We conducted a case-control study of 301 gastric cancer patients and 313 cancer-free controls frequency-matched by age, sex and ethnicity. We genotyped four selected TNFAIP2 SNPs (rs8126 T>C, rs710100 G>A, rs1052912 G>A and rs1052823 G>T) and used the logistic regression analysis to assess associations of these SNPs with cancer risk.The rs8126 CC genotype was associated with a significantly elevated risk of gastric cancer (adjusted OR = 2.00, 95% CI = 1.09-3.64 and P = 0.024), compared with the combined rs8126 TT+TC genotypes, particularly in current drinkers. However, none of other TNFAIP2 SNPs was associated with risk of gastric cancer.Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies. |
url |
http://europepmc.org/articles/PMC3665554?pdf=render |
work_keys_str_mv |
AT yuxu themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT hongxiama themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT hongpingyu themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT zhenshengliu themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT liewang themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT dongfengtan themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT ramyamuddasani themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT victorialu themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT jafferaajani themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT yanongwang themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT qingyiwei themir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT yuxu mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT hongxiama mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT hongpingyu mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT zhenshengliu mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT liewang mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT dongfengtan mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT ramyamuddasani mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT victorialu mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT jafferaajani mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT yanongwang mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer AT qingyiwei mir184bindingsiters8126tcpolymorphismintnfaip2isassociatedwithriskofgastriccancer |
_version_ |
1724896384536018944 |