Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis
Rui Tian,1,* Hong Xun Ye,2,* Bao Guo Zhang,3 Dong Ying Gu,3 Bing Wen Zhang,1 Zhi Pan Teng,1 Mao Yong Jin,4 Jin Fei Chen,3 Jian Wei Qi1 1Department of E.N.T., Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Oncology, The People’s Hospital of Taixing, Taixing, 3D...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2015-11-01
|
Series: | OncoTargets and Therapy |
Online Access: | https://www.dovepress.com/use-of-taxane-containing-induction-chemotherapy-in-combination-with-co-peer-reviewed-article-OTT |
id |
doaj-ef825c9adf8b4da4b9ce2db8119e095e |
---|---|
record_format |
Article |
spelling |
doaj-ef825c9adf8b4da4b9ce2db8119e095e2020-11-25T00:53:15ZengDove Medical PressOncoTargets and Therapy1178-69302015-11-012015default3255326324503Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysisTian RYe HXZhang BGGu DYZhang BWTeng ZPJin MYChen JFQi JWRui Tian,1,* Hong Xun Ye,2,* Bao Guo Zhang,3 Dong Ying Gu,3 Bing Wen Zhang,1 Zhi Pan Teng,1 Mao Yong Jin,4 Jin Fei Chen,3 Jian Wei Qi1 1Department of E.N.T., Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Oncology, The People’s Hospital of Taixing, Taixing, 3Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 4Department of Technology, Nanjing Delta Biotechnology Co., Ltd., Nanjing, People’s Republic of China *These authors contributed equally to this work Purpose: Taxane-containing induction chemotherapy (IC) regimens in combination with concurrent chemoradiotherapy (CCRT) have been compared with non-taxane-containing IC combined with CCRT in randomized controlled trials (RCTs) in Chinese patients with advanced nasopharyngeal carcinoma (NPC). This meta-analysis aimed to systematically evaluate their clinical efficacy and safety profiling in this ethnic population.Methods: The electronic databases, PubMed, Embase, MEDLINE, and Chinese Biomedical Database, were searched for eligible studies. The outcomes included overall response rate (ORR), 1-year survival rate, and different types of adverse events. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations.Results: A total of 12 RCTs (representing 835 patients) were identified. The pooled analysis showed that taxane-containing regimens had a significant improvement in ORR for nasopharyngeal lesion (OR =4.57, 95% CI =1.14–18.30, P=0.032, z=2.15) but not in cervical lymph nodes (OR =1.23, 95% CI =0.65–2.36, P=0.532, z=0.64) and in 1-year survival rates (OR =1.19, 95% CI =0.10–14.82, P=0.893, z=0.13) compared with non-taxane-containing regimens. Regarding the adverse events and toxicities, grade 3–4 leukopenia and neutropenia were significantly different between the two groups (P<0.001) in favor of the non-taxane-containing regimens, but grade 3–4 vomiting was significantly different between the two groups (P<0.005) in favor of the taxane-containing regimens.Conclusion: When combined with CCRT, taxane-containing IC regimens may be more efficient for short-term local control in Chinese patients with locally advanced NPC than the non-taxane-containing IC regimens. Moreover, the major toxic effects, which were bone marrow suppression, could be tolerated by majority of patients. More long-term follow-up and high-quality trials of NPC are needed to validate our findings.Keywords: randomized controlled trials, clinical efficacy, safety, survival rate, adverse events, cervical lymph nodeshttps://www.dovepress.com/use-of-taxane-containing-induction-chemotherapy-in-combination-with-co-peer-reviewed-article-OTT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian R Ye HX Zhang BG Gu DY Zhang BW Teng ZP Jin MY Chen JF Qi JW |
spellingShingle |
Tian R Ye HX Zhang BG Gu DY Zhang BW Teng ZP Jin MY Chen JF Qi JW Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis OncoTargets and Therapy |
author_facet |
Tian R Ye HX Zhang BG Gu DY Zhang BW Teng ZP Jin MY Chen JF Qi JW |
author_sort |
Tian R |
title |
Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis |
title_short |
Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis |
title_full |
Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis |
title_fullStr |
Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis |
title_full_unstemmed |
Use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in Chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis |
title_sort |
use of taxane-containing induction chemotherapy in combination with concurrent chemoradiotherapy in chinese patients with locally advanced nasopharyngeal carcinoma: a meta-analysis |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2015-11-01 |
description |
Rui Tian,1,* Hong Xun Ye,2,* Bao Guo Zhang,3 Dong Ying Gu,3 Bing Wen Zhang,1 Zhi Pan Teng,1 Mao Yong Jin,4 Jin Fei Chen,3 Jian Wei Qi1 1Department of E.N.T., Nanjing First Hospital, Nanjing Medical University, Nanjing, 2Department of Oncology, The People’s Hospital of Taixing, Taixing, 3Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 4Department of Technology, Nanjing Delta Biotechnology Co., Ltd., Nanjing, People’s Republic of China *These authors contributed equally to this work Purpose: Taxane-containing induction chemotherapy (IC) regimens in combination with concurrent chemoradiotherapy (CCRT) have been compared with non-taxane-containing IC combined with CCRT in randomized controlled trials (RCTs) in Chinese patients with advanced nasopharyngeal carcinoma (NPC). This meta-analysis aimed to systematically evaluate their clinical efficacy and safety profiling in this ethnic population.Methods: The electronic databases, PubMed, Embase, MEDLINE, and Chinese Biomedical Database, were searched for eligible studies. The outcomes included overall response rate (ORR), 1-year survival rate, and different types of adverse events. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations.Results: A total of 12 RCTs (representing 835 patients) were identified. The pooled analysis showed that taxane-containing regimens had a significant improvement in ORR for nasopharyngeal lesion (OR =4.57, 95% CI =1.14–18.30, P=0.032, z=2.15) but not in cervical lymph nodes (OR =1.23, 95% CI =0.65–2.36, P=0.532, z=0.64) and in 1-year survival rates (OR =1.19, 95% CI =0.10–14.82, P=0.893, z=0.13) compared with non-taxane-containing regimens. Regarding the adverse events and toxicities, grade 3–4 leukopenia and neutropenia were significantly different between the two groups (P<0.001) in favor of the non-taxane-containing regimens, but grade 3–4 vomiting was significantly different between the two groups (P<0.005) in favor of the taxane-containing regimens.Conclusion: When combined with CCRT, taxane-containing IC regimens may be more efficient for short-term local control in Chinese patients with locally advanced NPC than the non-taxane-containing IC regimens. Moreover, the major toxic effects, which were bone marrow suppression, could be tolerated by majority of patients. More long-term follow-up and high-quality trials of NPC are needed to validate our findings.Keywords: randomized controlled trials, clinical efficacy, safety, survival rate, adverse events, cervical lymph nodes |
url |
https://www.dovepress.com/use-of-taxane-containing-induction-chemotherapy-in-combination-with-co-peer-reviewed-article-OTT |
work_keys_str_mv |
AT tianr useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT yehx useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT zhangbg useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT gudy useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT zhangbw useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT tengzp useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT jinmy useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT chenjf useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis AT qijw useoftaxanecontaininginductionchemotherapyincombinationwithconcurrentchemoradiotherapyinchinesepatientswithlocallyadvancednasopharyngealcarcinomaametaanalysis |
_version_ |
1725238498776055808 |