Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors

Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human cochlear duct progenitors for in vitro hair cel...

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Main Authors:	Marta Roccio, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller, Pascal Senn
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06334-7

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spelling	doaj-ef8b80e88905450bad32986f1237e72b2021-05-11T10:25:36ZengNature Publishing GroupNature Communications2041-17232018-10-019111410.1038/s41467-018-06334-7Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitorsMarta Roccio0Michael Perny1Megan Ealy2Hans Ruedi Widmer3Stefan Heller4Pascal Senn5Laboratory of Inner Ear Research, Department of Biomedical Research, University of BernLaboratory of Inner Ear Research, Department of Biomedical Research, University of BernDepartment of Otolaryngology, Head and Neck Surgery, Stanford University School of MedicineDepartment of Neurosurgery, Neurocenter and Regenerative Neuroscience Cluster, Inselspital BernDepartment of Otolaryngology, Head and Neck Surgery, Stanford University School of MedicineLaboratory of Inner Ear Research, Department of Biomedical Research, University of BernHearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human cochlear duct progenitors for in vitro hair cell differentiation.https://doi.org/10.1038/s41467-018-06334-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marta Roccio Michael Perny Megan Ealy Hans Ruedi Widmer Stefan Heller Pascal Senn
spellingShingle	Marta Roccio Michael Perny Megan Ealy Hans Ruedi Widmer Stefan Heller Pascal Senn Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors Nature Communications
author_facet	Marta Roccio Michael Perny Megan Ealy Hans Ruedi Widmer Stefan Heller Pascal Senn
author_sort	Marta Roccio
title	Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
title_short	Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
title_full	Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
title_fullStr	Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
title_full_unstemmed	Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
title_sort	molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human cochlear duct progenitors for in vitro hair cell differentiation.
url	https://doi.org/10.1038/s41467-018-06334-7
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Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors

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