Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>

Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>

Fluorescence imaging offers a new approach to visualize real-time details on a cellular level <i>in vitro</i> and <i>in vivo</i> without radioactive damage. Poor light stability of organic fluorescent dyes makes long-term imaging difficult. Due to their outstanding optical pr...

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Main Authors: Yu Wang, Nan Xu, Yongkai He, Jingyun Wang, Dan Wang, Qin Gao, Siyu Xie, Yage Li, Ranran Zhang, Qiang Cai
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Materials
Subjects:
GQDs
real-time tracking
optical-magneto nanoparticles
<i>in vivo</i>
Online Access:https://www.mdpi.com/1996-1944/12/13/2191
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spelling doaj-ef8db1fdff4344429b2c2c16ace1767f2020-11-25T00:29:17ZengMDPI AGMaterials1996-19442019-07-011213219110.3390/ma12132191ma12132191Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>Yu Wang0Nan Xu1Yongkai He2Jingyun Wang3Dan Wang4Qin Gao5Siyu Xie6Yage Li7Ranran Zhang8Qiang Cai9State key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaShenzhen Geim Graphene Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaState key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, ChinaFluorescence imaging offers a new approach to visualize real-time details on a cellular level <i>in vitro</i> and <i>in vivo</i> without radioactive damage. Poor light stability of organic fluorescent dyes makes long-term imaging difficult. Due to their outstanding optical properties and unique structural features, graphene quantum dots (GQDs) are promising in the field of imaging for real-time tracking <i>in vivo</i>. At present, GQDs are mainly loaded on the surface of nanoparticles. In this study, we developed an efficient and convenient one-pot method to load GQDs into nanoparticles, leading to longer metabolic processes in blood and increased delivery of GQDs to tumors. Optical-magneto ferroferric oxide@polypyrrole (Fe<sub>3</sub>O<sub>4</sub>@PPy) core-shell nanoparticles were chosen for their potential use in cancer therapy. The <i>in vivo</i> results demonstrated that by loading GQDs, it was possible to monitor the distribution and metabolism of nanoparticles. This study provided new insights into the application of GQDs in long-term <i>in vivo</i> real-time tracking.https://www.mdpi.com/1996-1944/12/13/2191GQDsreal-time trackingoptical-magneto nanoparticles<i>in vivo</i>
collection DOAJ
language English
format Article
sources DOAJ
author Yu Wang
Nan Xu
Yongkai He
Jingyun Wang
Dan Wang
Qin Gao
Siyu Xie
Yage Li
Ranran Zhang
Qiang Cai
spellingShingle Yu Wang
Nan Xu
Yongkai He
Jingyun Wang
Dan Wang
Qin Gao
Siyu Xie
Yage Li
Ranran Zhang
Qiang Cai
Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>
Materials
GQDs
real-time tracking
optical-magneto nanoparticles
<i>in vivo</i>
author_facet Yu Wang
Nan Xu
Yongkai He
Jingyun Wang
Dan Wang
Qin Gao
Siyu Xie
Yage Li
Ranran Zhang
Qiang Cai
author_sort Yu Wang
title Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>
title_short Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>
title_full Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>
title_fullStr Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>
title_full_unstemmed Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking <i>In Vivo</i>
title_sort loading graphene quantum dots into optical-magneto nanoparticles for real-time tracking <i>in vivo</i>
publisher MDPI AG
series Materials
issn 1996-1944
publishDate 2019-07-01
description Fluorescence imaging offers a new approach to visualize real-time details on a cellular level <i>in vitro</i> and <i>in vivo</i> without radioactive damage. Poor light stability of organic fluorescent dyes makes long-term imaging difficult. Due to their outstanding optical properties and unique structural features, graphene quantum dots (GQDs) are promising in the field of imaging for real-time tracking <i>in vivo</i>. At present, GQDs are mainly loaded on the surface of nanoparticles. In this study, we developed an efficient and convenient one-pot method to load GQDs into nanoparticles, leading to longer metabolic processes in blood and increased delivery of GQDs to tumors. Optical-magneto ferroferric oxide@polypyrrole (Fe<sub>3</sub>O<sub>4</sub>@PPy) core-shell nanoparticles were chosen for their potential use in cancer therapy. The <i>in vivo</i> results demonstrated that by loading GQDs, it was possible to monitor the distribution and metabolism of nanoparticles. This study provided new insights into the application of GQDs in long-term <i>in vivo</i> real-time tracking.
topic GQDs
real-time tracking
optical-magneto nanoparticles
<i>in vivo</i>
url https://www.mdpi.com/1996-1944/12/13/2191
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AT qingao loadinggraphenequantumdotsintoopticalmagnetonanoparticlesforrealtimetrackingiinvivoi
AT siyuxie loadinggraphenequantumdotsintoopticalmagnetonanoparticlesforrealtimetrackingiinvivoi
AT yageli loadinggraphenequantumdotsintoopticalmagnetonanoparticlesforrealtimetrackingiinvivoi
AT ranranzhang loadinggraphenequantumdotsintoopticalmagnetonanoparticlesforrealtimetrackingiinvivoi
AT qiangcai loadinggraphenequantumdotsintoopticalmagnetonanoparticlesforrealtimetrackingiinvivoi
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