DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease
Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. High-dose intravenous immunoglobulin (IVIG) is the most effective therapy for KD to reduce the prevalence of coronary artery lesion (CAL) formation. Recently, the α2, 6 sialylated IgG was reported to interact with a l...
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doaj-ef91eef55e9c45898d2d7c719505aa512020-11-25T00:30:59ZengHindawi LimitedThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/634835634835DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki DiseaseHong-Ren Yu0Wei-Pin Chang1Lin Wang2Ying-Jui Lin3Chi-Di Liang4Kuender D. Yang5Chiu-Ming Kuo6Yi-Chuan Huang7Wei-Chiao Chang8Ho-Chang Kuo9Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDepartment of Healthcare Management, Yuanpei University, Hsinchu 30015, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDepartment of Medical Research and Pediatrics, Show Chwan Memorial Hospital in Chang Bing, Changhua 505, TaiwanDepartment of Nursing, Chang Gung Memorial Hospital, Chiayi, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanKawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. High-dose intravenous immunoglobulin (IVIG) is the most effective therapy for KD to reduce the prevalence of coronary artery lesion (CAL) formation. Recently, the α2, 6 sialylated IgG was reported to interact with a lectin receptor, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 (SIGN-R1) in mice and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) in human, and to trigger an anti-inflammatory cascade. This study was conducted to investigate whether the polymorphism of DC-SIGN (CD209) promoter −336 A/G (rs4804803) is responsible for susceptibility and CAL formation in KD patients using Custom TaqMan SNP Genotyping Assays. A total of 521 subjects (278 KD patients and 243 controls) were investigated to identify an SNP of rs4804803, and they were studied and showed a significant association between the genotypes and allele frequency of rs4804803 in control subjects and KD patients (P=0.004 under the dominant model). However, the promoter variant of DC-SIGN gene was not associated with the occurrence of IVIG resistance, CAL formation in KD. The G allele of DC-SIGN promoter −336 (rs4804803) is a risk allele in the development of KD.http://dx.doi.org/10.1100/2012/634835 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong-Ren Yu Wei-Pin Chang Lin Wang Ying-Jui Lin Chi-Di Liang Kuender D. Yang Chiu-Ming Kuo Yi-Chuan Huang Wei-Chiao Chang Ho-Chang Kuo |
spellingShingle |
Hong-Ren Yu Wei-Pin Chang Lin Wang Ying-Jui Lin Chi-Di Liang Kuender D. Yang Chiu-Ming Kuo Yi-Chuan Huang Wei-Chiao Chang Ho-Chang Kuo DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease The Scientific World Journal |
author_facet |
Hong-Ren Yu Wei-Pin Chang Lin Wang Ying-Jui Lin Chi-Di Liang Kuender D. Yang Chiu-Ming Kuo Yi-Chuan Huang Wei-Chiao Chang Ho-Chang Kuo |
author_sort |
Hong-Ren Yu |
title |
DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease |
title_short |
DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease |
title_full |
DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease |
title_fullStr |
DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease |
title_full_unstemmed |
DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease |
title_sort |
dc-sign (cd209) promoter −336 a/g (rs4804803) polymorphism associated with susceptibility of kawasaki disease |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
1537-744X |
publishDate |
2012-01-01 |
description |
Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. High-dose intravenous immunoglobulin (IVIG) is the most effective therapy for KD to reduce the prevalence of coronary artery lesion (CAL) formation. Recently, the α2, 6 sialylated IgG was reported to interact with a lectin receptor, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 (SIGN-R1) in mice and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) in human, and to trigger an anti-inflammatory cascade. This study was conducted to investigate whether the polymorphism of DC-SIGN (CD209) promoter −336 A/G (rs4804803) is responsible for susceptibility and CAL formation in KD patients using Custom TaqMan SNP Genotyping Assays. A total of 521 subjects (278 KD patients and 243 controls) were investigated to identify an SNP of rs4804803, and they were studied and showed a significant association between the genotypes and allele frequency of rs4804803 in control subjects and KD patients (P=0.004 under the dominant model). However, the promoter variant of DC-SIGN gene was not associated with the occurrence of IVIG resistance, CAL formation in KD. The G allele of DC-SIGN promoter −336 (rs4804803) is a risk allele in the development of KD. |
url |
http://dx.doi.org/10.1100/2012/634835 |
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