Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis
Mortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multipl...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-4601/18/14/7249 |
id |
doaj-ef9733323f094b45b58709b3791acaee |
---|---|
record_format |
Article |
spelling |
doaj-ef9733323f094b45b58709b3791acaee2021-07-23T13:43:12ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-07-01187249724910.3390/ijerph18147249Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death AnalysisAlessandro Marcon0Elena Schievano1Ugo Fedeli2Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Strada Le Grazie 8, 37134 Verona, ItalyEpidemiological Department, Azienda Zero Regione del Veneto, via Jacopo Avanzo 35, 35132 Padova, ItalyEpidemiological Department, Azienda Zero Regione del Veneto, via Jacopo Avanzo 35, 35132 Padova, ItalyMortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multiple cause of death analyses, and to describe the impact of the COVID-19 epidemic in 2020. We identified IPF (ICD-10 code J84.1) among the causes of death registered in 557,932 certificates in the Veneto region. We assessed time trends in annual age-standardized mortality rates by gender and age (40–74, 75–84, and ≥85 years). IPF was the underlying cause of 1310 deaths in the 2251 certificates mentioning IPF. For all age groups combined, the age-standardized mortality rate from IPF identified as the underlying cause of death was close to the European median (males and females: 3.1 and 1.3 per 100,000/year, respectively). During 2008–2019, mortality rates increased in men aged ≥85 years (annual percent change of 6.5%, 95% CI: 2.0, 11.2%), but not among women or for the younger age groups. A 72% excess of IPF-related deaths was registered in March–April 2020 (mortality ratio 1.72, 95% CI: 1.29, 2.24). IPF mortality was increasing among older men in northeastern Italy. The burden of IPF was heavier than assessed by routine statistics, since less than two out of three IPF-related deaths were directly attributed to this condition. COVID-19 was accompanied by a remarkable increase in IPF-related mortality.https://www.mdpi.com/1660-4601/18/14/7249idiopathic pulmonary fibrosismortalitytime trends analysismultiple cause of deathunderlying cause of deathCOVID-19 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessandro Marcon Elena Schievano Ugo Fedeli |
spellingShingle |
Alessandro Marcon Elena Schievano Ugo Fedeli Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis International Journal of Environmental Research and Public Health idiopathic pulmonary fibrosis mortality time trends analysis multiple cause of death underlying cause of death COVID-19 |
author_facet |
Alessandro Marcon Elena Schievano Ugo Fedeli |
author_sort |
Alessandro Marcon |
title |
Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis |
title_short |
Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis |
title_full |
Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis |
title_fullStr |
Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis |
title_full_unstemmed |
Mortality Associated with Idiopathic Pulmonary Fibrosis in Northeastern Italy, 2008–2020: A Multiple Cause of Death Analysis |
title_sort |
mortality associated with idiopathic pulmonary fibrosis in northeastern italy, 2008–2020: a multiple cause of death analysis |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-07-01 |
description |
Mortality from idiopathic pulmonary fibrosis (IPF) is increasing in most European countries, but there are no data for Italy. We analysed the registry data from a region in northeastern Italy to assess the trends in IPF-related mortality during 2008–2019, to compare results of underlying vs. multiple cause of death analyses, and to describe the impact of the COVID-19 epidemic in 2020. We identified IPF (ICD-10 code J84.1) among the causes of death registered in 557,932 certificates in the Veneto region. We assessed time trends in annual age-standardized mortality rates by gender and age (40–74, 75–84, and ≥85 years). IPF was the underlying cause of 1310 deaths in the 2251 certificates mentioning IPF. For all age groups combined, the age-standardized mortality rate from IPF identified as the underlying cause of death was close to the European median (males and females: 3.1 and 1.3 per 100,000/year, respectively). During 2008–2019, mortality rates increased in men aged ≥85 years (annual percent change of 6.5%, 95% CI: 2.0, 11.2%), but not among women or for the younger age groups. A 72% excess of IPF-related deaths was registered in March–April 2020 (mortality ratio 1.72, 95% CI: 1.29, 2.24). IPF mortality was increasing among older men in northeastern Italy. The burden of IPF was heavier than assessed by routine statistics, since less than two out of three IPF-related deaths were directly attributed to this condition. COVID-19 was accompanied by a remarkable increase in IPF-related mortality. |
topic |
idiopathic pulmonary fibrosis mortality time trends analysis multiple cause of death underlying cause of death COVID-19 |
url |
https://www.mdpi.com/1660-4601/18/14/7249 |
work_keys_str_mv |
AT alessandromarcon mortalityassociatedwithidiopathicpulmonaryfibrosisinnortheasternitaly20082020amultiplecauseofdeathanalysis AT elenaschievano mortalityassociatedwithidiopathicpulmonaryfibrosisinnortheasternitaly20082020amultiplecauseofdeathanalysis AT ugofedeli mortalityassociatedwithidiopathicpulmonaryfibrosisinnortheasternitaly20082020amultiplecauseofdeathanalysis |
_version_ |
1721288181030060032 |