IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1

IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1

Cytokine-amplified functional CD8+ T cells ensure effective eradication of tumors. Interleukin 36α (IL-36α), IL-36β, and IL-36γ share the same receptor complex, composed of the IL-36 receptor (IL-36R), and IL-1RAcP. Recently, we revealed that IL-36γ greatly promoted CD8+ T cell activation, contribut...

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Bibliographic Details
Main Authors: Xin Zhao, Xiaojuan Chen, Xinghua Shen, Peijun Tang, Chen Chen, Qitai Zhu, Muyao Li, Rui Xia, Xi Yang, Chao Feng, Xinguo Zhu, Yibei Zhu, Zhongwen Sun, Xueguang Zhang, Binfeng Lu, Xuefeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
IL-36β
CD8+ T cells
mTORC1
antitumor immune responses
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01803/full

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