EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.
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Nature Publishing Group
2016-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13685 |
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doaj-efa3d063166f4765ab0158eaae143a1b2021-05-11T10:43:21ZengNature Publishing GroupNature Communications2041-17232016-11-017111210.1038/ncomms13685EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophyJulian C. Lui0Presley Garrison1Quang Nguyen2Michal Ad3Chithra Keembiyehetty4Weiping Chen5Youn Hee Jee6Ellie Landman7Ola Nilsson8Kevin M. Barnes9Jeffrey Baron10Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthSection on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthSection on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthSection on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthGenomic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthGenomic Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthSection on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthDivision of Pediatric Endocrinology. Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University HospitalDivision of Pediatric Endocrinology. Q2:08, Department of Women’s and Children’s Health, Karolinska Institutet and University HospitalSection on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthSection on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthEZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.https://doi.org/10.1038/ncomms13685 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Julian C. Lui Presley Garrison Quang Nguyen Michal Ad Chithra Keembiyehetty Weiping Chen Youn Hee Jee Ellie Landman Ola Nilsson Kevin M. Barnes Jeffrey Baron |
| spellingShingle |
Julian C. Lui Presley Garrison Quang Nguyen Michal Ad Chithra Keembiyehetty Weiping Chen Youn Hee Jee Ellie Landman Ola Nilsson Kevin M. Barnes Jeffrey Baron EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy Nature Communications |
| author_facet |
Julian C. Lui Presley Garrison Quang Nguyen Michal Ad Chithra Keembiyehetty Weiping Chen Youn Hee Jee Ellie Landman Ola Nilsson Kevin M. Barnes Jeffrey Baron |
| author_sort |
Julian C. Lui |
| title |
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy |
| title_short |
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy |
| title_full |
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy |
| title_fullStr |
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy |
| title_full_unstemmed |
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy |
| title_sort |
ezh1 and ezh2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-11-01 |
| description |
EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development. |
| url |
https://doi.org/10.1038/ncomms13685 |
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