Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique
Macroporous scaffolds with controllable pore structure and mechanical properties were fabricated by a porogen fusion technique. Biodegradable material poly (D, L-lactide) (PDLLA) was used as the scaffold matrix. The effects of porogen size, PDLLA concentration and hydroxyapatite (HA) content on the...
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doaj-efa8712473f24f918c474ad0cc9b08992020-11-24T21:27:40ZengMDPI AGInternational Journal of Molecular Sciences1422-00672011-01-0112289090410.3390/ijms12020890Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion TechniqueChu ChenQinggang TanSonggang LiJie RenMacroporous scaffolds with controllable pore structure and mechanical properties were fabricated by a porogen fusion technique. Biodegradable material poly (D, L-lactide) (PDLLA) was used as the scaffold matrix. The effects of porogen size, PDLLA concentration and hydroxyapatite (HA) content on the scaffold morphology, porosity and mechanical properties were investigated. High porosity (90% and above) and highly interconnected structures were easily obtained and the pore size could be adjusted by varying the porogen size. With the increasing porogen size and PDLLA concentration, the porosity of scaffolds decreases, while its mechanical properties increase. The introduction of HA greatly increases the impact on pore structure, mechanical properties and water absorption ability of scaffolds, while it has comparatively little influence on its porosity under low HA contents. These results show that by adjusting processing parameters, scaffolds could afford a controllable pore size, exhibit suitable pore structure and high porosity, as well as good mechanical properties, and may serve as an excellent substrate for bone tissue engineering. http://www.mdpi.com/1422-0067/12/2/890/tissue engineeringcomposite scaffoldsmechanical propertyporogen fusion technique |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chu Chen Qinggang Tan Songgang Li Jie Ren |
spellingShingle |
Chu Chen Qinggang Tan Songgang Li Jie Ren Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique International Journal of Molecular Sciences tissue engineering composite scaffolds mechanical property porogen fusion technique |
author_facet |
Chu Chen Qinggang Tan Songgang Li Jie Ren |
author_sort |
Chu Chen |
title |
Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique |
title_short |
Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique |
title_full |
Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique |
title_fullStr |
Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique |
title_full_unstemmed |
Fabrication of Porous Scaffolds with a Controllable Microstructure and Mechanical Properties by Porogen Fusion Technique |
title_sort |
fabrication of porous scaffolds with a controllable microstructure and mechanical properties by porogen fusion technique |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2011-01-01 |
description |
Macroporous scaffolds with controllable pore structure and mechanical properties were fabricated by a porogen fusion technique. Biodegradable material poly (D, L-lactide) (PDLLA) was used as the scaffold matrix. The effects of porogen size, PDLLA concentration and hydroxyapatite (HA) content on the scaffold morphology, porosity and mechanical properties were investigated. High porosity (90% and above) and highly interconnected structures were easily obtained and the pore size could be adjusted by varying the porogen size. With the increasing porogen size and PDLLA concentration, the porosity of scaffolds decreases, while its mechanical properties increase. The introduction of HA greatly increases the impact on pore structure, mechanical properties and water absorption ability of scaffolds, while it has comparatively little influence on its porosity under low HA contents. These results show that by adjusting processing parameters, scaffolds could afford a controllable pore size, exhibit suitable pore structure and high porosity, as well as good mechanical properties, and may serve as an excellent substrate for bone tissue engineering. |
topic |
tissue engineering composite scaffolds mechanical property porogen fusion technique |
url |
http://www.mdpi.com/1422-0067/12/2/890/ |
work_keys_str_mv |
AT chuchen fabricationofporousscaffoldswithacontrollablemicrostructureandmechanicalpropertiesbyporogenfusiontechnique AT qinggangtan fabricationofporousscaffoldswithacontrollablemicrostructureandmechanicalpropertiesbyporogenfusiontechnique AT songgangli fabricationofporousscaffoldswithacontrollablemicrostructureandmechanicalpropertiesbyporogenfusiontechnique AT jieren fabricationofporousscaffoldswithacontrollablemicrostructureandmechanicalpropertiesbyporogenfusiontechnique |
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1725974163170000896 |