Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives

Synthesis, characterization and antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives

A novel series of hybrid 4-aminoquinolines-1,3,5-triazine were synthesized by means of aromatic nucleophilic displacement of chlorine atoms of 2,4,6-trichloro-1,3,5-triazine. Afforded title analogs were subsequently characterised by elemental analysis, FT-IR, 1H NMR, 13C NMR and mass spectroscopy an...

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Bibliographic Details
Main Authors: Hans Raj Bhat, Udaya Pratap Singh, Pankaj S. Yadav, Vikas Kumar, Prashant Gahtori, Aparoop Das, Dipak Chetia, Anil Prakash, J. Mahanta
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Arabian Journal of Chemistry
Subjects:
Antimalarial
4-Aminoquinoline
1,3,5-Triazine
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535211001845
Description
Summary:A novel series of hybrid 4-aminoquinolines-1,3,5-triazine were synthesized by means of aromatic nucleophilic displacement of chlorine atoms of 2,4,6-trichloro-1,3,5-triazine. Afforded title analogs were subsequently characterised by elemental analysis, FT-IR, 1H NMR, 13C NMR and mass spectroscopy and subjected to screening against chloroquine sensitive RKL2 strain of Plasmodium falciparum in 96 well-microtitre plates. However, synthesized derivatives exhibit mild to moderate antimalarial activity and acute toxicity studies of the most active (6a and 6g) compounds were shown to have no significant change in body insight and toxic sign.
ISSN:1878-5352

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