The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections
Human papillomaviruses (HPV) are the causative agents of the most common sexually transmitted infection worldwide. While infection is generally asymptomatic and can be cleared by the host immune system, when persistence occurs, HPV can become a risk factor for malignant transformation. Progression t...
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doaj-efb2172d47c040459d24914b614473272020-11-25T02:04:20ZengMDPI AGCancers2072-66942020-03-0112364610.3390/cancers12030646cancers12030646The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus InfectionsAna Rita Ferreira0Ana Catarina Ramalho1Mariana Marques2Daniela Ribeiro3Institute of Biomedicine—iBiMED & Department of Medical Sciences, University of Aveiro, 3810-198 Aveiro, PortugalInstitute of Biomedicine—iBiMED & Department of Medical Sciences, University of Aveiro, 3810-198 Aveiro, PortugalInstitute of Biomedicine—iBiMED & Department of Medical Sciences, University of Aveiro, 3810-198 Aveiro, PortugalInstitute of Biomedicine—iBiMED & Department of Medical Sciences, University of Aveiro, 3810-198 Aveiro, PortugalHuman papillomaviruses (HPV) are the causative agents of the most common sexually transmitted infection worldwide. While infection is generally asymptomatic and can be cleared by the host immune system, when persistence occurs, HPV can become a risk factor for malignant transformation. Progression to cancer is actually an unintended consequence of the complex HPV life cycle. Different antiviral defence mechanisms recognize HPV early in infection, leading to the activation of the innate immune response. However, the virus has evolved several specific strategies to efficiently evade the antiviral immune signalling. Here, we review and discuss the interplay between HPV and the host cell innate immunity. We further highlight the evasion strategies developed by different HPV to escape this cellular response and focus on the correlation with HPV-induced persistence and tumorigenesis.https://www.mdpi.com/2072-6694/12/3/646human papillomavirusinnate immunitycancerintracellular antiviral responseimmune evasion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Rita Ferreira Ana Catarina Ramalho Mariana Marques Daniela Ribeiro |
spellingShingle |
Ana Rita Ferreira Ana Catarina Ramalho Mariana Marques Daniela Ribeiro The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections Cancers human papillomavirus innate immunity cancer intracellular antiviral response immune evasion |
author_facet |
Ana Rita Ferreira Ana Catarina Ramalho Mariana Marques Daniela Ribeiro |
author_sort |
Ana Rita Ferreira |
title |
The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections |
title_short |
The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections |
title_full |
The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections |
title_fullStr |
The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections |
title_full_unstemmed |
The Interplay between Antiviral Signalling and Carcinogenesis in Human Papillomavirus Infections |
title_sort |
interplay between antiviral signalling and carcinogenesis in human papillomavirus infections |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-03-01 |
description |
Human papillomaviruses (HPV) are the causative agents of the most common sexually transmitted infection worldwide. While infection is generally asymptomatic and can be cleared by the host immune system, when persistence occurs, HPV can become a risk factor for malignant transformation. Progression to cancer is actually an unintended consequence of the complex HPV life cycle. Different antiviral defence mechanisms recognize HPV early in infection, leading to the activation of the innate immune response. However, the virus has evolved several specific strategies to efficiently evade the antiviral immune signalling. Here, we review and discuss the interplay between HPV and the host cell innate immunity. We further highlight the evasion strategies developed by different HPV to escape this cellular response and focus on the correlation with HPV-induced persistence and tumorigenesis. |
topic |
human papillomavirus innate immunity cancer intracellular antiviral response immune evasion |
url |
https://www.mdpi.com/2072-6694/12/3/646 |
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