Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report
Motor neuron diseases have been reported as a rare paraneoplastic syndrome (PNS) of a systemic neoplasm. We present a patient with amyotrophic lateral sclerosis (ALS) in association with neuroendocrine tumor (NET) of stomach, which is the first case of motor neuronopathy with underlying neuroendocr...
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Tehran University of Medical Sciences
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doaj-efbd5cca813840799b44711588df8a682020-11-25T03:23:25ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942013-10-0151104327Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case ReportMasoud Mehrpour0Nafiseh Mohebi1Mohammad Reza Motamed2Farhad Zamani3Department of Neurology, Firoozgar General Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Neurology, Firoozgar General Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Neurology, Firoozgar General Hospital, Tehran University of Medical Sciences, Tehran, Iran.Gastrointestinal and Liver Diseases Research Center, Firoozgar General Hospital, Tehran University of Medical Sciences, Tehran, Iran. Motor neuron diseases have been reported as a rare paraneoplastic syndrome (PNS) of a systemic neoplasm. We present a patient with amyotrophic lateral sclerosis (ALS) in association with neuroendocrine tumor (NET) of stomach, which is the first case of motor neuronopathy with underlying neuroendocrine tumor. A 79-year old woman presented with a two months history of progressive dysphagia, spastic dysarthria and marked fasciculation in her atrophic tongue. Gag reflexes were diminished bilaterally. Other cranial nerves were intact. In muscle testing there was significant atrophy in thenar and hypothenar areas of both hands compatible with diffuse motor neuronopathy with active denervation. Upper GI endoscopic study showed patchy erythematous mucosa with congestion in body of stomach, Histological biopsy of stomach confirmed the neuroendocrine tumor (NET). The importance of considering a paraneoplastic syndrome in a patient with presentation of ALS, which can leads to searching for underlying neoplasm before its apparent signs and symptoms, to initiate tumor treatment so much sooner. In addition even though paraneoplastic motor neuron disease is rare, treating the underlying neoplasm may resolve neurologic signs and symptoms. https://acta.tums.ac.ir/index.php/acta/article/view/4374Amyotrophic lateral sclerosis (ALS)Neuroendocrine tumors (NETs)Paraneoplastic syndromes (PNSs) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masoud Mehrpour Nafiseh Mohebi Mohammad Reza Motamed Farhad Zamani |
spellingShingle |
Masoud Mehrpour Nafiseh Mohebi Mohammad Reza Motamed Farhad Zamani Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report Acta Medica Iranica Amyotrophic lateral sclerosis (ALS) Neuroendocrine tumors (NETs) Paraneoplastic syndromes (PNSs) |
author_facet |
Masoud Mehrpour Nafiseh Mohebi Mohammad Reza Motamed Farhad Zamani |
author_sort |
Masoud Mehrpour |
title |
Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report |
title_short |
Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report |
title_full |
Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report |
title_fullStr |
Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report |
title_full_unstemmed |
Amyotrophic Lateral Sclerosis As A Paraneoplastic Manifestation in the Neuroendocrine Tumor of Stomach: A Case Report |
title_sort |
amyotrophic lateral sclerosis as a paraneoplastic manifestation in the neuroendocrine tumor of stomach: a case report |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2013-10-01 |
description |
Motor neuron diseases have been reported as a rare paraneoplastic syndrome (PNS) of a systemic neoplasm. We present a patient with amyotrophic lateral sclerosis (ALS) in association with neuroendocrine tumor (NET) of stomach, which is the first case of motor neuronopathy with underlying neuroendocrine tumor. A 79-year old woman presented with a two months history of progressive dysphagia, spastic dysarthria and marked fasciculation in her atrophic tongue. Gag reflexes were diminished bilaterally. Other cranial nerves were intact. In muscle testing there was significant atrophy in thenar and hypothenar areas of both hands compatible with diffuse motor neuronopathy with active denervation. Upper GI endoscopic study showed patchy erythematous mucosa with congestion in body of stomach, Histological biopsy of stomach confirmed the neuroendocrine tumor (NET). The importance of considering a paraneoplastic syndrome in a patient with presentation of ALS, which can leads to searching for underlying neoplasm before its apparent signs and symptoms, to initiate tumor treatment so much sooner. In addition even though paraneoplastic motor neuron disease is rare, treating the underlying neoplasm may resolve neurologic signs and symptoms.
|
topic |
Amyotrophic lateral sclerosis (ALS) Neuroendocrine tumors (NETs) Paraneoplastic syndromes (PNSs) |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/4374 |
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