Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells

Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells

Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental factor that affects the development of RA. Metabolites secreted by the gut microbiota maint...

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Bibliographic Details
Main Authors: Da Som Kim, Jeong-Eun Kwon, Seung Hoon Lee, Eun Kyung Kim, Jun-Geol Ryu, Kyung-Ah Jung, Jeong-Won Choi, Min-Jung Park, Young-Mee Moon, Sung-Hwan Park, Mi-La Cho, Seung-Ki Kwok
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
sodium butyrate
rheumatoid arthritis
histone deacetylases
glucocorticoid receptor
ERRα
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01525/full

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