Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa
Neuroimaging studies investigating the neural profile of anorexia nervosa (AN) have revealed a predominant imbalance between the reward and inhibition systems of the brain, which are also hallmark characteristics of the disorder. However, little is known whether these changes can also be determined...
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doaj-efca212f4e7b4f488c9ff17ec1649db32020-11-25T00:18:36ZengElsevierNeuroImage: Clinical2213-15822014-01-014C61562210.1016/j.nicl.2014.04.002Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosaStephanie Kullmann0Katrin E. Giel1Martin Teufel2Ansgar Thiel3Stephan Zipfel4Hubert Preissl5Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, GermanyInstitute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University, Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital, Tübingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Medical University Hospital, Tübingen, GermanyInstitute of Sport Science, University Tübingen, Tübingen, GermanyInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, GermanyNeuroimaging studies investigating the neural profile of anorexia nervosa (AN) have revealed a predominant imbalance between the reward and inhibition systems of the brain, which are also hallmark characteristics of the disorder. However, little is known whether these changes can also be determined independent of task condition, using resting-state functional magnetic resonance imaging, in currently ill AN patients. Therefore the aim of our study was to investigate resting-state connectivity in AN patients (n = 12) compared to healthy athlete (n = 12) and non-athlete (n = 14) controls. For this purpose, we used degree centrality to investigate functional connectivity of the whole-brain network and then Granger causality to analyze effective connectivity (EC), to understand directional aspects of potential alterations. We were able to show that the bilateral inferior frontal gyrus (IFG) is a region of special functional importance within the whole-brain network, in AN patients, revealing reduced functional connectivity compared to both healthy control groups. Furthermore, we found decreased EC from the right IFG to the midcingulum and increased EC from the bilateral orbitofrontal gyrus to the right IFG. For the left IFG, we only observed increased EC from the bilateral insula to the left IFG. These results suggest that AN patients have reduced connectivity within the cognitive control system of the brain and increased connectivity within regions important for salience processing. Due to its fundamental role in inhibitory behavior, including motor response, altered integrity of the inferior frontal cortex could contribute to hyperactivity in AN.http://www.sciencedirect.com/science/article/pii/S2213158214000461Anorexia nervosaFunctional connectivityEffective connectivityResting-state fMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie Kullmann Katrin E. Giel Martin Teufel Ansgar Thiel Stephan Zipfel Hubert Preissl |
spellingShingle |
Stephanie Kullmann Katrin E. Giel Martin Teufel Ansgar Thiel Stephan Zipfel Hubert Preissl Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa NeuroImage: Clinical Anorexia nervosa Functional connectivity Effective connectivity Resting-state fMRI |
author_facet |
Stephanie Kullmann Katrin E. Giel Martin Teufel Ansgar Thiel Stephan Zipfel Hubert Preissl |
author_sort |
Stephanie Kullmann |
title |
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa |
title_short |
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa |
title_full |
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa |
title_fullStr |
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa |
title_full_unstemmed |
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa |
title_sort |
aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2014-01-01 |
description |
Neuroimaging studies investigating the neural profile of anorexia nervosa (AN) have revealed a predominant imbalance between the reward and inhibition systems of the brain, which are also hallmark characteristics of the disorder. However, little is known whether these changes can also be determined independent of task condition, using resting-state functional magnetic resonance imaging, in currently ill AN patients.
Therefore the aim of our study was to investigate resting-state connectivity in AN patients (n = 12) compared to healthy athlete (n = 12) and non-athlete (n = 14) controls. For this purpose, we used degree centrality to investigate functional connectivity of the whole-brain network and then Granger causality to analyze effective connectivity (EC), to understand directional aspects of potential alterations.
We were able to show that the bilateral inferior frontal gyrus (IFG) is a region of special functional importance within the whole-brain network, in AN patients, revealing reduced functional connectivity compared to both healthy control groups. Furthermore, we found decreased EC from the right IFG to the midcingulum and increased EC from the bilateral orbitofrontal gyrus to the right IFG. For the left IFG, we only observed increased EC from the bilateral insula to the left IFG.
These results suggest that AN patients have reduced connectivity within the cognitive control system of the brain and increased connectivity within regions important for salience processing. Due to its fundamental role in inhibitory behavior, including motor response, altered integrity of the inferior frontal cortex could contribute to hyperactivity in AN. |
topic |
Anorexia nervosa Functional connectivity Effective connectivity Resting-state fMRI |
url |
http://www.sciencedirect.com/science/article/pii/S2213158214000461 |
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