Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice.
Methicillin-resistant S. aureus emerged in recent decades to become a leading cause of infection worldwide. Colonization with MRSA predisposes to infection and facilitates transmission of the pathogen; however, available regimens are ineffective at preventing MRSA colonization. Studies of human nasa...
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2011-01-01
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doaj-efcae87b0eb14b1cb6a800bc8a910c7f2020-11-25T00:23:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01610e2588010.1371/journal.pone.0025880Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice.Bonggoo ParkTadayuki IwaseGeorge Y LiuMethicillin-resistant S. aureus emerged in recent decades to become a leading cause of infection worldwide. Colonization with MRSA predisposes to infection and facilitates transmission of the pathogen; however, available regimens are ineffective at preventing MRSA colonization. Studies of human nasal flora suggest that resident bacteria play a critical role in limiting S. aureus growth, and prompted us to query whether application of commensal resident bacteria could prevent nasal colonization with MRSA. We established a murine model system to study this question, and showed that mice nasally pre-colonized with S. epidermidis became more resistant to colonization with MRSA. Our study suggests that application of commensal bacteria with antibiotics could represent a more effective strategy to prevent MRSA colonization.http://europepmc.org/articles/PMC3187813?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bonggoo Park Tadayuki Iwase George Y Liu |
spellingShingle |
Bonggoo Park Tadayuki Iwase George Y Liu Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice. PLoS ONE |
author_facet |
Bonggoo Park Tadayuki Iwase George Y Liu |
author_sort |
Bonggoo Park |
title |
Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice. |
title_short |
Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice. |
title_full |
Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice. |
title_fullStr |
Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice. |
title_full_unstemmed |
Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice. |
title_sort |
intranasal application of s. epidermidis prevents colonization by methicillin-resistant staphylococcus aureus in mice. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Methicillin-resistant S. aureus emerged in recent decades to become a leading cause of infection worldwide. Colonization with MRSA predisposes to infection and facilitates transmission of the pathogen; however, available regimens are ineffective at preventing MRSA colonization. Studies of human nasal flora suggest that resident bacteria play a critical role in limiting S. aureus growth, and prompted us to query whether application of commensal resident bacteria could prevent nasal colonization with MRSA. We established a murine model system to study this question, and showed that mice nasally pre-colonized with S. epidermidis became more resistant to colonization with MRSA. Our study suggests that application of commensal bacteria with antibiotics could represent a more effective strategy to prevent MRSA colonization. |
url |
http://europepmc.org/articles/PMC3187813?pdf=render |
work_keys_str_mv |
AT bonggoopark intranasalapplicationofsepidermidispreventscolonizationbymethicillinresistantstaphylococcusaureusinmice AT tadayukiiwase intranasalapplicationofsepidermidispreventscolonizationbymethicillinresistantstaphylococcusaureusinmice AT georgeyliu intranasalapplicationofsepidermidispreventscolonizationbymethicillinresistantstaphylococcusaureusinmice |
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1725357213714743296 |