Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model

Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model

Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse model. Adult control Tor1a+/+ and mutant Tor1a...

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Bibliographic Details
Main Authors: Vincenza D’Angelo, Emanuela Paldino, Silvia Cardarelli, Roberto Sorge, Francesca Romana Fusco, Stefano Biagioni, Nicola Biagio Mercuri, Mauro Giorgi, Giuseppe Sancesario
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
dystonia
striatum
d2 receptors
synapses
dopamine volume transmission
Online Access:https://www.mdpi.com/1422-0067/21/3/1073

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