Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis
Objective: To study the correlation between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis. Methods: 36 children who were diagnosed with sepsis in Children’s Hospital of Hebei Province between June 2014 and December 2016 were selected as sepsis gr...
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doaj-efd13899eb1e46b19c2645ec6116dc982020-11-24T23:19:50ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-06-0123129194Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsisHai-Xia Chang10Li-Bo Zhang21Zhong-Fu Zhang121. Emergency Department, Children’s Hospital of Hebei Province, Shijiazhuang 050031, China2. The Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China1. Emergency Department, Children’s Hospital of Hebei Province, Shijiazhuang 050031, ChinaObjective: To study the correlation between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis. Methods: 36 children who were diagnosed with sepsis in Children’s Hospital of Hebei Province between June 2014 and December 2016 were selected as sepsis group, and healthy volunteer children who received physical examination during the same period were selected as control group. Peripheral blood was collected to determine the content of CD4+CD25+Treg cells, and the serum was collected to determine the contents of the inflammatory mediators and oxidative stress products. Results: Peripheral blood CD4+CD25+Treg cell level in sepsis group was significantly higher than that in control group. Serum ICAM-1, TNF-α, IL-1β, CRP, PCT, LPO, MDA and AOPPs levels in sepsis group were significantly higher those in control group; serum ICAM-1, TNF-α, IL- 1β, CRP, PCT, LPO, MDA and AOPPs levels in sepsis children with high Treg level were significantly higher than those in sepsis children with low Treg level. Conclusion: Increased levels of CD4+CD25+Treg cells in patients with sepsis can activate systemic inflammatory response and oxidative stress response.http://www.hnykdxxb.com/PDF/201712/24.pdfSepsis Regulatory T cell Inflammatory response Oxidative stress response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai-Xia Chang1 Li-Bo Zhang2 Zhong-Fu Zhang1 |
spellingShingle |
Hai-Xia Chang1 Li-Bo Zhang2 Zhong-Fu Zhang1 Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis Journal of Hainan Medical University Sepsis Regulatory T cell Inflammatory response Oxidative stress response |
author_facet |
Hai-Xia Chang1 Li-Bo Zhang2 Zhong-Fu Zhang1 |
author_sort |
Hai-Xia Chang1 |
title |
Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis |
title_short |
Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis |
title_full |
Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis |
title_fullStr |
Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis |
title_full_unstemmed |
Correlation study between peripheral blood CD4+CD25+Treg levels and systemic inflammatory response in patients with sepsis |
title_sort |
correlation study between peripheral blood cd4+cd25+treg levels and systemic inflammatory response in patients with sepsis |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-06-01 |
description |
Objective: To study the correlation between peripheral blood CD4+CD25+Treg levels and
systemic inflammatory response in patients with sepsis. Methods: 36 children who were
diagnosed with sepsis in Children’s Hospital of Hebei Province between June 2014 and
December 2016 were selected as sepsis group, and healthy volunteer children who received
physical examination during the same period were selected as control group. Peripheral blood
was collected to determine the content of CD4+CD25+Treg cells, and the serum was collected
to determine the contents of the inflammatory mediators and oxidative stress products. Results:
Peripheral blood CD4+CD25+Treg cell level in sepsis group was significantly higher than that
in control group. Serum ICAM-1, TNF-α, IL-1β, CRP, PCT, LPO, MDA and AOPPs levels
in sepsis group were significantly higher those in control group; serum ICAM-1, TNF-α, IL-
1β, CRP, PCT, LPO, MDA and AOPPs levels in sepsis children with high Treg level were
significantly higher than those in sepsis children with low Treg level. Conclusion: Increased
levels of CD4+CD25+Treg cells in patients with sepsis can activate systemic inflammatory
response and oxidative stress response. |
topic |
Sepsis Regulatory T cell Inflammatory response Oxidative stress response |
url |
http://www.hnykdxxb.com/PDF/201712/24.pdf |
work_keys_str_mv |
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1725576604680192000 |