PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasoma...
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Nature Publishing Group
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25252-9 |
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doaj-efd9b3f404b3443ca49e78b32652785a2021-08-22T11:39:38ZengNature Publishing GroupNature Communications2041-17232021-08-0112111610.1038/s41467-021-25252-9PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylationYilun Sun0Jiji Chen1Shar-yin N. Huang2Yijun P. Su3Wenjie Wang4Keli Agama5Sourav Saha6Lisa M. Jenkins7John M. Pascal8Yves Pommier9Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHAdvanced Imaging and Microscopy Resource, National Institute of Biomedical Imaging and Bioengineering, NIHDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHAdvanced Imaging and Microscopy Resource, National Institute of Biomedical Imaging and Bioengineering, NIHDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHCollaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, NIHDepartment of Biochemistry and Molecular Medicine, Université de MontréalDevelopmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIHTOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.https://doi.org/10.1038/s41467-021-25252-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier |
| spellingShingle |
Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation Nature Communications |
| author_facet |
Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier |
| author_sort |
Yilun Sun |
| title |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
| title_short |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
| title_full |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
| title_fullStr |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
| title_full_unstemmed |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
| title_sort |
parylation prevents the proteasomal degradation of topoisomerase i dna-protein crosslinks and induces their deubiquitylation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-08-01 |
| description |
TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc. |
| url |
https://doi.org/10.1038/s41467-021-25252-9 |
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