Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

RNA polymerases (RNAPs) contain a conserved ‘secondary channel’ which binds regulatory factors that modulate transcription initiation. In Escherichia coli, the secondary channel factors (SCFs) GreB and DksA both repress ribosomal RNA (rRNA) transcription, but SCF loading and repression mechanisms ar...

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Bibliographic Details
Main Authors: Sarah K Stumper, Harini Ravi, Larry J Friedman, Rachel Anne Mooney, Ivan R Corrêa Jnr, Anne Gershenson, Robert Landick, Jeff Gelles
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
GreB
DksA
single-molecule fluorescence
CoSMoS
TIRF
Online Access:https://elifesciences.org/articles/40576

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