An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431

An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431

A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated f...

Full description

Bibliographic Details
Main Authors: Chunshun Li, Ariel M. Sarotti, Xiaohua Wu, Baojun Yang, James Turkson, Yongfei Chen, Qingsong Liu, Shugeng Cao
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
endophytic fungi
Peyronellaea
benzoisoquinoline-9-one
antiproliferative
Hawaii
Online Access:http://www.mdpi.com/1420-3049/24/1/196
id doaj-efee239c0cc94608a074bc6a73130be9
record_format Article
spelling doaj-efee239c0cc94608a074bc6a73130be92020-11-25T02:42:01ZengMDPI AGMolecules1420-30492019-01-0124119610.3390/molecules24010196molecules24010196An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431Chunshun Li0Ariel M. Sarotti1Xiaohua Wu2Baojun Yang3James Turkson4Yongfei Chen5Qingsong Liu6Shugeng Cao7Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USAInstituto de Química Rosario (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, ArgentinaDepartment of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USACancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USACancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USAHigh Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaHigh Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaDepartment of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USAA new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 μM.http://www.mdpi.com/1420-3049/24/1/196endophytic fungiPeyronellaeabenzoisoquinoline-9-oneantiproliferativeHawaii
collection DOAJ
language English
format Article
sources DOAJ
author Chunshun Li
Ariel M. Sarotti
Xiaohua Wu
Baojun Yang
James Turkson
Yongfei Chen
Qingsong Liu
Shugeng Cao
spellingShingle Chunshun Li
Ariel M. Sarotti
Xiaohua Wu
Baojun Yang
James Turkson
Yongfei Chen
Qingsong Liu
Shugeng Cao
An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
Molecules
endophytic fungi
Peyronellaea
benzoisoquinoline-9-one
antiproliferative
Hawaii
author_facet Chunshun Li
Ariel M. Sarotti
Xiaohua Wu
Baojun Yang
James Turkson
Yongfei Chen
Qingsong Liu
Shugeng Cao
author_sort Chunshun Li
title An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
title_short An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
title_full An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
title_fullStr An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
title_full_unstemmed An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic Fungus Peyronellaea sp. FT431
title_sort unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from hawaiian endophytic fungus peyronellaea sp. ft431
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-01-01
description A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 μM.
topic endophytic fungi
Peyronellaea
benzoisoquinoline-9-one
antiproliferative
Hawaii
url http://www.mdpi.com/1420-3049/24/1/196
work_keys_str_mv AT chunshunli anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT arielmsarotti anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT xiaohuawu anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT baojunyang anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT jamesturkson anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT yongfeichen anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT qingsongliu anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT shugengcao anunusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT chunshunli unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT arielmsarotti unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT xiaohuawu unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT baojunyang unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT jamesturkson unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT yongfeichen unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT qingsongliu unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
AT shugengcao unusualbenzoisoquinoline9onederivativeandotherrelatedcompoundswithantiproliferativeactivityfromhawaiianendophyticfunguspeyronellaeaspft431
_version_ 1724775885903495168

Similar Items