In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate
The in vitro bioactivity of slightly hypereutectic glass-ceramics of the pseudo-binary system diopside (CMS2, CaMgSi2O6)–tricalcium phosphate [Ca3P, Ca3(PO4)2], was tested in a Simulated Body Fluid (SBF) from 7 to 21 days at pH = 7.3 and 36.5 °C. The materials were synthesized by the petrurgic metho...
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doaj-eff20656b0d1426cbae6c7b1f0494f172021-04-04T04:17:38ZengElsevierBoletín de la Sociedad Española de Cerámica y Vidrio0366-31752021-03-016028392In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphateJorge López-Cuevas0Claudia Magdalena López-Badillo1Juan Méndez-Nonell2Cinvestav Unidad Saltillo, Calle Industria Metalúrgica, Número 1062, Parque Industrial Saltillo - Ramos Arizpe, Ramos Arizpe, Coahuila, Mexico; Corresponding author.Universidad Autónoma de Coahuila, Facultad de Ciencias Químicas, Blvd. Venustiano Carranza S/N, Colonia República Oriente, Saltillo, Coahuila, MexicoCinvestav Unidad Saltillo, Calle Industria Metalúrgica, Número 1062, Parque Industrial Saltillo - Ramos Arizpe, Ramos Arizpe, Coahuila, MexicoThe in vitro bioactivity of slightly hypereutectic glass-ceramics of the pseudo-binary system diopside (CMS2, CaMgSi2O6)–tricalcium phosphate [Ca3P, Ca3(PO4)2], was tested in a Simulated Body Fluid (SBF) from 7 to 21 days at pH = 7.3 and 36.5 °C. The materials were synthesized by the petrurgic method, using cooling rates of 0.5, 1 and 2 °C/h through the mushy zone. Their microstructure consisted of β-C3Pss (solid solution of CMS2 in Ca3P) primary dendrites in a matrix of CMS2–β-C3Pss lamellar eutectic phase. The dissolution of the interdendritic matrix into the SBF lead to the formation of an interconnected porous structure at the surface of the samples. Subsequently, the β-C3Pss primary dendrites were pseudomorphically converted into (Ca10−yMgy)(PO4)6−z(SiO4)z(OH)2−z (Mg and Si co-substituted hydroxyapatite, HAp). The cavities left by the dissolved matrix were then filled with HAp, and a layer of this phase was formed on the surface of the material. The rate of dissolution of the material's matrix into the SBF, the rate of precipitation of HAp from the solution, the composition of the precipitated HAp, and pH and ionic composition of the SBF during the tests, were all affected by the cooling rate used to synthesize the materials. Resumen: La bioactividad in vitro de vitrocerámicas ligeramente hipereutécticas del sistema seudobinario diópsido (CMS2, CaMgSi2O6)–fosfato tricálcico [Ca3P, Ca3(PO4)2], se probó en un fluido fisiológico simulado (FFS) por 7 a 21 días a pH = 7.3 y 36.5 °C. Los materiales sintetizados por el método petrúrgico, usando velocidades de enfriamiento de 0.5, 1 y 2 °C/h a través de la zona de transición sólido/líquido, presentaron una microestructura de dendritas primarias de β-C3Pss (solución sólida de CMS2 en Ca3P) en una matriz de fase eutéctica laminar de CMS2–β-C3Pss. La disolución de la matriz en el FFS creó una estructura porosa interconectada en la superficie de las muestras. Posteriormente, las dendritas primarias de β-C3Pss se convirtieron seudomórficamente en (Ca10−yMgy)(PO4)6−z(SiO4)z(OH)2−z (hidroxiapatita, HAp, co-sustituida con Mg y Si). Las cavidades creadas al disolverse la matriz se llenaron con HAp, y se formó una capa de esta misma fase sobre la superficie del material. Las velocidades de disolución de la matriz en el FFS y de precipitación de la HAp de la solución, la composición de la HAp precipitada, y el pH y la composición iónica del FFS durante las pruebas, fueron afectados por la velocidad de enfriamiento utilizada para sintetizar los materiales.http://www.sciencedirect.com/science/article/pii/S0366317520300170SíntesisBiomaterialesVitrocerámicas |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jorge López-Cuevas Claudia Magdalena López-Badillo Juan Méndez-Nonell |
spellingShingle |
Jorge López-Cuevas Claudia Magdalena López-Badillo Juan Méndez-Nonell In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate Boletín de la Sociedad Española de Cerámica y Vidrio Síntesis Biomateriales Vitrocerámicas |
author_facet |
Jorge López-Cuevas Claudia Magdalena López-Badillo Juan Méndez-Nonell |
author_sort |
Jorge López-Cuevas |
title |
In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate |
title_short |
In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate |
title_full |
In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate |
title_fullStr |
In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate |
title_full_unstemmed |
In vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate |
title_sort |
in vitro bioactivity of a glass-ceramic biomaterial with near-eutectic composition of the pseudo-binary system diopside–tricalcium phosphate |
publisher |
Elsevier |
series |
Boletín de la Sociedad Española de Cerámica y Vidrio |
issn |
0366-3175 |
publishDate |
2021-03-01 |
description |
The in vitro bioactivity of slightly hypereutectic glass-ceramics of the pseudo-binary system diopside (CMS2, CaMgSi2O6)–tricalcium phosphate [Ca3P, Ca3(PO4)2], was tested in a Simulated Body Fluid (SBF) from 7 to 21 days at pH = 7.3 and 36.5 °C. The materials were synthesized by the petrurgic method, using cooling rates of 0.5, 1 and 2 °C/h through the mushy zone. Their microstructure consisted of β-C3Pss (solid solution of CMS2 in Ca3P) primary dendrites in a matrix of CMS2–β-C3Pss lamellar eutectic phase. The dissolution of the interdendritic matrix into the SBF lead to the formation of an interconnected porous structure at the surface of the samples. Subsequently, the β-C3Pss primary dendrites were pseudomorphically converted into (Ca10−yMgy)(PO4)6−z(SiO4)z(OH)2−z (Mg and Si co-substituted hydroxyapatite, HAp). The cavities left by the dissolved matrix were then filled with HAp, and a layer of this phase was formed on the surface of the material. The rate of dissolution of the material's matrix into the SBF, the rate of precipitation of HAp from the solution, the composition of the precipitated HAp, and pH and ionic composition of the SBF during the tests, were all affected by the cooling rate used to synthesize the materials. Resumen: La bioactividad in vitro de vitrocerámicas ligeramente hipereutécticas del sistema seudobinario diópsido (CMS2, CaMgSi2O6)–fosfato tricálcico [Ca3P, Ca3(PO4)2], se probó en un fluido fisiológico simulado (FFS) por 7 a 21 días a pH = 7.3 y 36.5 °C. Los materiales sintetizados por el método petrúrgico, usando velocidades de enfriamiento de 0.5, 1 y 2 °C/h a través de la zona de transición sólido/líquido, presentaron una microestructura de dendritas primarias de β-C3Pss (solución sólida de CMS2 en Ca3P) en una matriz de fase eutéctica laminar de CMS2–β-C3Pss. La disolución de la matriz en el FFS creó una estructura porosa interconectada en la superficie de las muestras. Posteriormente, las dendritas primarias de β-C3Pss se convirtieron seudomórficamente en (Ca10−yMgy)(PO4)6−z(SiO4)z(OH)2−z (hidroxiapatita, HAp, co-sustituida con Mg y Si). Las cavidades creadas al disolverse la matriz se llenaron con HAp, y se formó una capa de esta misma fase sobre la superficie del material. Las velocidades de disolución de la matriz en el FFS y de precipitación de la HAp de la solución, la composición de la HAp precipitada, y el pH y la composición iónica del FFS durante las pruebas, fueron afectados por la velocidad de enfriamiento utilizada para sintetizar los materiales. |
topic |
Síntesis Biomateriales Vitrocerámicas |
url |
http://www.sciencedirect.com/science/article/pii/S0366317520300170 |
work_keys_str_mv |
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