Autophagy: A Novel Horizon for Hair Cell Protection
As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the develop...
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Hindawi Limited
2021-01-01
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Series: | Neural Plasticity |
Online Access: | http://dx.doi.org/10.1155/2021/5511010 |
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doaj-eff310219fd4459281f9772c48e9229b2021-07-12T02:12:05ZengHindawi LimitedNeural Plasticity1687-54432021-01-01202110.1155/2021/5511010Autophagy: A Novel Horizon for Hair Cell ProtectionChang Liu0Zhiwei Zheng1Pengjun Wang2Shuangba He3Yingzi He4ENT Institute and Otorhinolaryngology DepartmentENT Institute and Otorhinolaryngology DepartmentDepartment of OtorhinolaryngologyDepartment of Otolaryngology Head and NeckENT Institute and Otorhinolaryngology DepartmentAs a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.http://dx.doi.org/10.1155/2021/5511010 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He |
spellingShingle |
Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He Autophagy: A Novel Horizon for Hair Cell Protection Neural Plasticity |
author_facet |
Chang Liu Zhiwei Zheng Pengjun Wang Shuangba He Yingzi He |
author_sort |
Chang Liu |
title |
Autophagy: A Novel Horizon for Hair Cell Protection |
title_short |
Autophagy: A Novel Horizon for Hair Cell Protection |
title_full |
Autophagy: A Novel Horizon for Hair Cell Protection |
title_fullStr |
Autophagy: A Novel Horizon for Hair Cell Protection |
title_full_unstemmed |
Autophagy: A Novel Horizon for Hair Cell Protection |
title_sort |
autophagy: a novel horizon for hair cell protection |
publisher |
Hindawi Limited |
series |
Neural Plasticity |
issn |
1687-5443 |
publishDate |
2021-01-01 |
description |
As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs. |
url |
http://dx.doi.org/10.1155/2021/5511010 |
work_keys_str_mv |
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_version_ |
1721308177172004864 |