Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort
Abstract Background A validated, standardized, and feasible test to assess muscle power in older adults has recently been reported: the sit‐to‐stand (STS) muscle power test. This investigation aimed to assess the relationship between relative STS power and age and to provide normative data, cut‐off...
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Wiley
2021-08-01
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Series: | Journal of Cachexia, Sarcopenia and Muscle |
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Online Access: | https://doi.org/10.1002/jcsm.12737 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julian Alcazar Luis M. Alegre Evelien Van Roie João P. Magalhães Barbara R. Nielsen Marcela González‐Gross Pedro B. Júdice Jose A. Casajús Christophe Delecluse Luis B. Sardinha Charlotte Suetta Ignacio Ara |
spellingShingle |
Julian Alcazar Luis M. Alegre Evelien Van Roie João P. Magalhães Barbara R. Nielsen Marcela González‐Gross Pedro B. Júdice Jose A. Casajús Christophe Delecluse Luis B. Sardinha Charlotte Suetta Ignacio Ara Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort Journal of Cachexia, Sarcopenia and Muscle Chair stand Mobility limitations Muscle Sarcopenia Intrinsic capacity Functional ability |
author_facet |
Julian Alcazar Luis M. Alegre Evelien Van Roie João P. Magalhães Barbara R. Nielsen Marcela González‐Gross Pedro B. Júdice Jose A. Casajús Christophe Delecluse Luis B. Sardinha Charlotte Suetta Ignacio Ara |
author_sort |
Julian Alcazar |
title |
Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort |
title_short |
Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort |
title_full |
Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort |
title_fullStr |
Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort |
title_full_unstemmed |
Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohort |
title_sort |
relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large european cohort |
publisher |
Wiley |
series |
Journal of Cachexia, Sarcopenia and Muscle |
issn |
2190-5991 2190-6009 |
publishDate |
2021-08-01 |
description |
Abstract Background A validated, standardized, and feasible test to assess muscle power in older adults has recently been reported: the sit‐to‐stand (STS) muscle power test. This investigation aimed to assess the relationship between relative STS power and age and to provide normative data, cut‐off points, and minimal clinically important differences (MCID) for STS power measures in older women and men. Methods A total of 9320 older adults (6161 women and 3159 men) aged 60–103 years and 586 young and middle‐aged adults (318 women and 268 men) aged 20–60 years were included in this cross‐sectional study. Relative (normalized to body mass), allometric (normalized to height squared), and specific (normalized to legs muscle mass) muscle power values were assessed by the 30 s STS power test. Body composition was evaluated by dual energy X‐ray absorptiometry and bioelectrical impedance analysis, and legs skeletal muscle index (SMI; normalized to height squared) was calculated. Habitual and maximal gait speed, timed up‐and‐go test, and 6 min walking distance were collected as physical performance measures, and participants were classified into two groups: well‐functioning and mobility‐limited older adults. Results Relative STS power was found to decrease between 30–50 years (−0.05 W·kg−1·year−1; P > 0.05), 50–80 years (−0.10 to −0.13 W·kg−1·year−1; P < 0.001), and above 80 years (−0.07 to −0.08 W·kg−1·year−1; P < 0.001). A total of 1129 older women (18%) and 510 older men (16%) presented mobility limitations. Mobility‐limited older adults were older and exhibited lower relative, allometric, and specific power; higher body mass index (BMI) and legs SMI (both only in women); and lower legs SMI (only in men) than their well‐functioning counterparts (all P < 0.05). Normative data and cut‐off points for relative, allometric, and specific STS power and for BMI and legs SMI were reported. Low relative STS power occurred below 2.1 W·kg−1 in women (area under the curve, AUC, [95% confidence interval, CI] = 0.85 [0.84–0.87]) and below 2.6 W·kg−1 in men (AUC [95% CI] = 0.89 [0.87–0.91]). The age‐adjusted odds ratios [95% CI] for mobility limitations in older women and men with low relative STS power were 10.6 [9.0–12.6] and 14.1 [10.9–18.2], respectively. MCID values for relative STS power were 0.33 W·kg−1 in women and 0.42 W·kg−1 in men. Conclusions Relative STS power decreased significantly after the age of 50 years and was negatively and strongly associated with mobility limitations. Our study provides normative data, functionally relevant cut‐off points, and MCID values for STS power for their use in daily clinical practice. |
topic |
Chair stand Mobility limitations Muscle Sarcopenia Intrinsic capacity Functional ability |
url |
https://doi.org/10.1002/jcsm.12737 |
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doaj-f0054693f5bf4e24888c7e8abad09ced2021-08-09T05:46:55ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092021-08-0112492193210.1002/jcsm.12737Relative sit‐to‐stand power: aging trajectories, functionally relevant cut‐off points, and normative data in a large European cohortJulian Alcazar0Luis M. Alegre1Evelien Van Roie2João P. Magalhães3Barbara R. Nielsen4Marcela González‐Gross5Pedro B. Júdice6Jose A. Casajús7Christophe Delecluse8Luis B. Sardinha9Charlotte Suetta10Ignacio Ara11GENUD Toledo Research Group Universidad de Castilla‐La Mancha Toledo SpainGENUD Toledo Research Group Universidad de Castilla‐La Mancha Toledo SpainDepartment of Movement Sciences, Physical Activity, Sports and Health Research Group KU Leuven Leuven BelgiumExercise and Health Laboratory, CIPER, Facultade de Motricidade Humana Universidade de Lisboa Lisbon PortugalDepartment of Internal Medicine, Geriatric Division Amager and Hvidovre Hospital, Glostrup Copenhagen DenmarkImFine Research Group, Departamento de Salud y Rendimiento Humano, Facultad de Ciencias de la Actividad Física y del Deporte Universidad Politécnica de Madrid Madrid SpainExercise and Health Laboratory, CIPER, Facultade de Motricidade Humana Universidade de Lisboa Lisbon PortugalCIBER of Pathophysiology of Obesity and Nutrition (CIBEROBN) Madrid SpainDepartment of Movement Sciences, Physical Activity, Sports and Health Research Group KU Leuven Leuven BelgiumExercise and Health Laboratory, CIPER, Facultade de Motricidade Humana Universidade de Lisboa Lisbon PortugalGeriatric Research Unit, Geriatric Department Bispebjerg‐Frederiksberg University Hospital Copenhagen DenmarkGENUD Toledo Research Group Universidad de Castilla‐La Mancha Toledo SpainAbstract Background A validated, standardized, and feasible test to assess muscle power in older adults has recently been reported: the sit‐to‐stand (STS) muscle power test. This investigation aimed to assess the relationship between relative STS power and age and to provide normative data, cut‐off points, and minimal clinically important differences (MCID) for STS power measures in older women and men. Methods A total of 9320 older adults (6161 women and 3159 men) aged 60–103 years and 586 young and middle‐aged adults (318 women and 268 men) aged 20–60 years were included in this cross‐sectional study. Relative (normalized to body mass), allometric (normalized to height squared), and specific (normalized to legs muscle mass) muscle power values were assessed by the 30 s STS power test. Body composition was evaluated by dual energy X‐ray absorptiometry and bioelectrical impedance analysis, and legs skeletal muscle index (SMI; normalized to height squared) was calculated. Habitual and maximal gait speed, timed up‐and‐go test, and 6 min walking distance were collected as physical performance measures, and participants were classified into two groups: well‐functioning and mobility‐limited older adults. Results Relative STS power was found to decrease between 30–50 years (−0.05 W·kg−1·year−1; P > 0.05), 50–80 years (−0.10 to −0.13 W·kg−1·year−1; P < 0.001), and above 80 years (−0.07 to −0.08 W·kg−1·year−1; P < 0.001). A total of 1129 older women (18%) and 510 older men (16%) presented mobility limitations. Mobility‐limited older adults were older and exhibited lower relative, allometric, and specific power; higher body mass index (BMI) and legs SMI (both only in women); and lower legs SMI (only in men) than their well‐functioning counterparts (all P < 0.05). Normative data and cut‐off points for relative, allometric, and specific STS power and for BMI and legs SMI were reported. Low relative STS power occurred below 2.1 W·kg−1 in women (area under the curve, AUC, [95% confidence interval, CI] = 0.85 [0.84–0.87]) and below 2.6 W·kg−1 in men (AUC [95% CI] = 0.89 [0.87–0.91]). The age‐adjusted odds ratios [95% CI] for mobility limitations in older women and men with low relative STS power were 10.6 [9.0–12.6] and 14.1 [10.9–18.2], respectively. MCID values for relative STS power were 0.33 W·kg−1 in women and 0.42 W·kg−1 in men. Conclusions Relative STS power decreased significantly after the age of 50 years and was negatively and strongly associated with mobility limitations. Our study provides normative data, functionally relevant cut‐off points, and MCID values for STS power for their use in daily clinical practice.https://doi.org/10.1002/jcsm.12737Chair standMobility limitationsMuscleSarcopeniaIntrinsic capacityFunctional ability |