Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids
Alpha lipoic acid (ALA) is a well-known anti-aging compound. The activity of this molecule is limited by two important factors: (i) The low stability to oxidation and thermal processes and (ii) the low solubility. Particularly the latter limits ALA formulation in hydrophilic bases. The purpose of th...
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doaj-f00e6fd30b314ba2b4810bbcc325cec32020-11-25T01:55:15ZengMDPI AGCosmetics2079-92842019-06-01623510.3390/cosmetics6020035cosmetics6020035Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite HybridsCinzia Pagano0Paola Calarco1Maria Rachele Ceccarini2Tommaso Beccari3Maurizio Ricci4Luana Perioli5Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, ItalyDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, ItalyDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, ItalyDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, ItalyDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, ItalyDipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, ItalyAlpha lipoic acid (ALA) is a well-known anti-aging compound. The activity of this molecule is limited by two important factors: (i) The low stability to oxidation and thermal processes and (ii) the low solubility. Particularly the latter limits ALA formulation in hydrophilic bases. The purpose of this paper is to present a new technological approach to stabilize lipoic acid in topical hydrogels for cosmetic use. With this aim, ALA was intercalated in two different lamellar anionic clays (hydrotalcites), MgAl and ZnAl, obtaining the hybrids MgAl-ALA and ZnAl-ALA. The intercalation allows to obtain a more manageable product in comparison to raw ALA. After the preliminary characterization, hydrogels containing the hybrids were prepared and characterized, also in comparison to the commercial product Tiobec<sup>®</sup> in terms of rheological properties, stability to temperature and centrifugation, release, and cytotoxicity. The obtained results highlighted that the hydrogel containing MgAl-ALA is a suitable alternative to the products currently available on the market.https://www.mdpi.com/2079-9284/6/2/35lipoic acidhydrotalciteintercalation producthybridshydrogelstabilityrheology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cinzia Pagano Paola Calarco Maria Rachele Ceccarini Tommaso Beccari Maurizio Ricci Luana Perioli |
spellingShingle |
Cinzia Pagano Paola Calarco Maria Rachele Ceccarini Tommaso Beccari Maurizio Ricci Luana Perioli Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids Cosmetics lipoic acid hydrotalcite intercalation product hybrids hydrogel stability rheology |
author_facet |
Cinzia Pagano Paola Calarco Maria Rachele Ceccarini Tommaso Beccari Maurizio Ricci Luana Perioli |
author_sort |
Cinzia Pagano |
title |
Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids |
title_short |
Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids |
title_full |
Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids |
title_fullStr |
Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids |
title_full_unstemmed |
Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids |
title_sort |
development and characterization of new topical hydrogels based on alpha lipoic acid—hydrotalcite hybrids |
publisher |
MDPI AG |
series |
Cosmetics |
issn |
2079-9284 |
publishDate |
2019-06-01 |
description |
Alpha lipoic acid (ALA) is a well-known anti-aging compound. The activity of this molecule is limited by two important factors: (i) The low stability to oxidation and thermal processes and (ii) the low solubility. Particularly the latter limits ALA formulation in hydrophilic bases. The purpose of this paper is to present a new technological approach to stabilize lipoic acid in topical hydrogels for cosmetic use. With this aim, ALA was intercalated in two different lamellar anionic clays (hydrotalcites), MgAl and ZnAl, obtaining the hybrids MgAl-ALA and ZnAl-ALA. The intercalation allows to obtain a more manageable product in comparison to raw ALA. After the preliminary characterization, hydrogels containing the hybrids were prepared and characterized, also in comparison to the commercial product Tiobec<sup>®</sup> in terms of rheological properties, stability to temperature and centrifugation, release, and cytotoxicity. The obtained results highlighted that the hydrogel containing MgAl-ALA is a suitable alternative to the products currently available on the market. |
topic |
lipoic acid hydrotalcite intercalation product hybrids hydrogel stability rheology |
url |
https://www.mdpi.com/2079-9284/6/2/35 |
work_keys_str_mv |
AT cinziapagano developmentandcharacterizationofnewtopicalhydrogelsbasedonalphalipoicacidhydrotalcitehybrids AT paolacalarco developmentandcharacterizationofnewtopicalhydrogelsbasedonalphalipoicacidhydrotalcitehybrids AT mariarachelececcarini developmentandcharacterizationofnewtopicalhydrogelsbasedonalphalipoicacidhydrotalcitehybrids AT tommasobeccari developmentandcharacterizationofnewtopicalhydrogelsbasedonalphalipoicacidhydrotalcitehybrids AT maurizioricci developmentandcharacterizationofnewtopicalhydrogelsbasedonalphalipoicacidhydrotalcitehybrids AT luanaperioli developmentandcharacterizationofnewtopicalhydrogelsbasedonalphalipoicacidhydrotalcitehybrids |
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